ArticleJournal of nephropathology2014
Effect of pomegranate flower extract on cisplatin-induced nephrotoxicity in rats.
Article in Journal of nephropathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Persistent Renal Oxidative Stress Despite Mannitol Nephroprotection: The Impact of Social-Single Prolonged Stress in Male and Female Rats Exposed to Cisplatin.Cell biochemistry and function · 2025Article
- Methadone and the Kidney: Dissecting Gender Differences in Inflammation and Oxidative Stress Responses.Addiction & health · 2025Article
- Evaluation of Renoprotective Effects of Our Locally Grown Green Coffee Beans against Cisplatin-Induced Nephrotoxicity in Swiss Albino Mice.International journal of nephrology · 2021Article
- Cisplatin chemotherapy and renal function.Advances in cancer research · 2021Review
- Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways.Biomolecules · 2020Article
- Article
- Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review.Journal of nephropathology · 2017Review
- Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender DifferencesAsian Pacific journal of cancer prevention : APJCP · 2017Review
- Negative Response of Phytoestrogens of Pomegranate Flower Extract against Cisplatin-induced Nephrotoxicity in Female Rats.International journal of preventive medicine · 2016Article
- Comment on: Effect of Pomegranate Flower Extract on Cisplatin-induced Nephrotoxicity in Male Rats.International journal of preventive medicine · 2016Article
- Comment on: Pomegranate Flower Extract Does Not Prevent Cisplatin-induced Nephrotoxicity in Female Rats.International journal of preventive medicine · 2015Article
- Pomegranate Flower Extract does not Prevent Cisplatin-Induced Nephrotoxicity in Female Rats.International journal of preventive medicine · 2014Article
- Comment on: effect of pomegranate flower extract oncis platin-induced nephrotoxicity in rats.Journal of nephropathology · 2014Article
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Authors and funding
10 authors.
Funding
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Abstract
backgroundChemotherapy with cisplatin (CP) is accompanied with nephrotoxicity.
objectivesIn the current study, pomegranate flower extract (PFE) has been evaluated as an antioxidant agent against CP-induced-renal toxicity. MATERIALS AND
methodsThirty two male Wistar rats were divided into five groups (6-8 in each group). The animals in groups 1 to 3 received PFE (25 mg/kg), PFE (50 mg/kg), and placebo (saline), respectively for 9 days, and onset of the day 3, they also received CP (2.5 mg/kg/day). Groups 4 and 5 were treated with PFE (25 and 50 mg/kg/day) for 9 days. Finally, the animals were sacrificed at day 9 after collecting blood samples. Kidneys were removed, weighted, and underwent histopathological investigation.
resultsThe mean serum level of creatinine in group 3 (treated with CP and placebo) increased significantly (p<0.05), but the value decreased significantly (p<0.05) in group 1. Kidney weight in group 1 was lower than KW in groups 2 and 3, however it was significant when compared with group 2 (p<0.05). The serum nitrite level in group 2 was non-significantly lower than that in other groups, and no significant changes were observed in serum levels of malondialdehyde (MDA). Tissue level of nitrite was significantly decreased in the positive control and high dose of PFE plus CP-treated groups (p<0.05). Among CP-treated groups, low dose of PFE significantly improved kidney nitrite level (p<0.05). The results from histopathological staining indicated less tissue damage in group 1 when compared with group 3.
conclusionsIt seems that low dose of PFE plays a protective role against CP-induced renal toxicity in rats.
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