ReviewWorld journal of nephrology2014
T-cell ageing in end-stage renal disease patients: Assessment and clinical relevance.
Review in World journal of nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Decreased Peripheral Naïve T Cell Number and Its Role in Predicting Cardiovascular and Infection Events in Hemodialysis Patients.Frontiers in immunology · 2021Trial
- V-J combinations of T-cell receptor predict responses to erythropoietin in end-stage renal disease patients.Journal of biomedical science · 2017Trial
- Loss of CD28 on Peripheral T Cells Decreases the Risk for Early Acute Rejection after Kidney Transplantation.PloS one · 2016Trial
- T-cell receptor Vβ repertoire skewing reflects premature immune senescence in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2026Article
- Kidney Disease as a Driver of Immunosenescence: Mechanisms and Potential Interventions.Journal of the American Society of Nephrology : JASN · 2026Review
- Association of systemic immune-inflammation index and systemic inflammation response index with chronic kidney disease: observational study of 40,937 adults.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Observational
- Factors associated with length of hospital stay among dialysis patients with nontraumatic acute abdomen: a retrospective observational study.Singapore medical journal · 2020Observational
- Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients.BMC nephrology · 2020Article
- Review
- Decreased B1 and B2 Lymphocytes Are Associated With Mortality in Elderly Patients With Chronic Kidney Diseases.Frontiers in medicine · 2020Article
- A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation.Immunity & ageing : I & A · 2020Article
- Effects of bariatric surgery on telomere length and T-cell aging.International journal of obesity (2005) · 2019Article
- Opportunistic parasitoses among Egyptian hemodialysis patients in relation to CD4+ T-cell counts: a comparative study.BMC infectious diseases · 2019Article
- Mortality risk after herpes zoster infection in end-stage renal disease patients.Clinical kidney journal · 2019Article
- Article
- Clinical and hematological data to group different chronic kidney disease patients: A practical approach to establish different groups of patients.Journal of clinical laboratory analysis · 2018Article
- The role of age-related T-cell differentiation in patients with renal replacement therapy.Immunology and cell biology · 2017Article
- Factors associated with the elevated percentage of CD4CD69 T cells in maintained hemodialysis patients.Renal failure · 2017Article
- Decreased percentage of peripheral naïve T cells is independently associated with ischemic stroke in patients on hemodialysis.International urology and nephrology · 2017Article
- Diabetes mellitus and extrapulmonary tuberculosis: site distribution and risk of mortality.Epidemiology and infection · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
End-stage renal disease (ESRD) patients have a defective T-cell-mediated immune system which is related to excessive premature ageing of the T-cell compartment. This is likely to be caused by the uremia-associated pro-inflammatory milieu, created by loss of renal function. Therefore, ESRD patients are highly susceptible for infections, have an increased risk for virus-associated cancers, respond poorly to vaccination and have an increased risk for atherosclerotic diseases. Three ageing parameters can be used to assess an immunological T-cell age. First, thymic output can be determined by assessing the T-cell receptor excision circles-content together with CD31 expression within the naïve T cells. Second, the telomere length of T cells and third the T-cell differentiation status are also indicators of T-cell ageing. Analyses based on these parameters in ESRD patients revealed that the immunological T-cell age is increased by on average 20 years compared to the chronological age. After kidney transplantation (KTx) the aged T-cell phenotype persists although the pro-inflammatory milieu is diminished. This might be explained by epigenetic modifications at hematopoietic stem cells level. Assessment of an immunological T-cell age could be an important tool to identify KTx recipients who are at risk for allograft rejection or to prevent over-immunosuppression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.