ArticlePeerJ2014
Characterization of the transcriptome, nucleotide sequence polymorphism, and natural selection in the desert adapted mouse Peromyscus eremicus.
Article in PeerJ, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Degrees of convergent evolution in rodent adaptations to arid environments.Genome research · 2026Article
- Concerted genetic and transcriptomic shifts underlie adaptation to a latitudinal thermal gradient within a widespread mantis shrimp.BMC ecology and evolution · 2025Article
- The multi-tissue gene expression and physiological responses of water deprived Peromyscus eremicus.BMC genomics · 2024Article
- When the tap runs dry: The multi-tissue gene expression and physiological responses of water deprivedbioRxiv : the preprint server for biology · 2024Article
- When the tap runs dry: the physiological effects of acute experimental dehydration in Peromyscus eremicus.The Journal of experimental biology · 2023Article
- Whole-genome sequencing reveals adaptations of hairy-footed jerboas (Dipus, Dipodidae) to diverse desert environments.BMC biology · 2023Article
- Lyme Disease Agent ReservoirsPathogens (Basel, Switzerland) · 2023Article
- Differential expression of epigenetic modifiers in early and late cardiotoxic heart failure reveals DNA methylation as a key regulator of cardiotoxicity.Frontiers in cardiovascular medicine · 2023Article
- Linking genetic, morphological, and behavioural divergence between inland island and mainland deer mice.Heredity · 2022Article
- Disentangling environmental drivers of circadian metabolism in desert-adapted mice.The Journal of experimental biology · 2021Article
- Life in Deserts: The Genetic Basis of Mammalian Desert Adaptation.Trends in ecology & evolution · 2021Review
- Limited Evidence for Parallel Evolution Among Desert-Adapted Peromyscus Deer Mice.The Journal of heredity · 2021Article
- Ion channel profiling of the Lymnaea stagnalis ganglia via transcriptome analysis.BMC genomics · 2021Article
- Apolipoprotein C1: Its Pleiotropic Effects in Lipid Metabolism and Beyond.International journal of molecular sciences · 2019Review
- De novo comparative transcriptome analysis of a rare cicada, with identification of candidate genes related to adaptation to a novel host plant and drier habitats.BMC genomics · 2019Article
- Contrasting patterns of divergence at the regulatory and sequence level in EuropeanEcology and evolution · 2019Article
- Signatures of positive selection and local adaptation to urbanization in white-footed mice (Peromyscus leucopus).Molecular ecology · 2017Article
- Characterizing the reproductive transcriptomic correlates of acute dehydration in males in the desert-adapted rodent, Peromyscus eremicus.BMC genomics · 2017Article
- Physiological and biochemical changes associated with acute experimental dehydration in the desert adapted mouse,Physiological reports · 2017Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
As a direct result of intense heat and aridity, deserts are thought to be among the most harsh of environments, particularly for their mammalian inhabitants. Given that osmoregulation can be challenging for these animals, with failure resulting in death, strong selection should be observed on genes related to the maintenance of water and solute balance. One such animal, Peromyscus eremicus, is native to the desert regions of the southwest United States and may live its entire life without oral fluid intake. As a first step toward understanding the genetics that underlie this phenotype, we present a characterization of the P. eremicus transcriptome. We assay four tissues (kidney, liver, brain, testes) from a single individual and supplement this with population level renal transcriptome sequencing from 15 additional animals. We identified a set of transcripts undergoing both purifying and balancing selection based on estimates of Tajima's D. In addition, we used the branch-site test to identify a transcript-Slc2a9, likely related to desert osmoregulation-undergoing enhanced selection in P. eremicus relative to a set of related non-desert rodents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.