ArticleTranslational vision science & technology2014
The Test-Retest Reliability of the Photopic Negative Response (PhNR).
Article in Translational vision science & technology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The rapid N-wave as a potentially useful measure of the photopic negative response.Documenta ophthalmologica. Advances in ophthalmology · 2020Trial
- The reproducibility of handheld ERGs recorded with skin electrode and natural pupils.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Ganglion cell function loss in extensive macular atrophy with pseudodrusen.International ophthalmology · 2025Observational
- Electroretinographic Findings in Fragile X, Premutation, and Controls: A Study of Biomarker Correlations.International journal of molecular sciences · 2025Article
- Electroretinography With the RM Electrode: Normative Reference Ranges, Variation With Age, and Comparison With the Burian-Allen Electrode.Translational vision science & technology · 2025Article
- Association analyses of the measurements of the photopic negative response evoked by two ISCEV protocols.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- A modified analysis protocol for the PhNR test.Documenta ophthalmologica. Advances in ophthalmology · 2024Article
- Retinal Ganglion Cell Function and Perfusion following Intraocular Pressure Reduction with Preservative-Free Latanoprost in Patients with Glaucoma and Ocular Hypertension.Journal of clinical medicine · 2024Article
- Investigating the Structural and Functional Changes in the Optic Nerve in Patients with Early Glaucoma Using the Optical Coherence Tomography (OCT) and RETeval System.Sensors (Basel, Switzerland) · 2023Article
- Comparing the RETevalDocumenta ophthalmologica. Advances in ophthalmology · 2023Article
- Monitoring for glaucoma progression with SAP, electroretinography (PERG and PhNR) and OCT.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- Clinical electrophysiology of the optic nerve and retinal ganglion cells.Eye (London, England) · 2021Review
- Relationship between structural and functional changes in glaucomatous eyes: a multifocal electroretinogram study.BMC ophthalmology · 2021Article
- Photopic negative response using a handheld mini-ganzfeld stimulator in healthy adults: normative values, intra- and inter-session variability.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- The photopic negative response (PhNR): measurement approaches and utility in glaucoma.International ophthalmology · 2020Review
- Short-Term Changes in the Photopic Negative Response Following Intraocular Pressure Lowering in Glaucoma.Investigative ophthalmology & visual science · 2020Article
- Factors Affecting Photopic Negative Response Recorded with RETTranslational vision science & technology · 2020Article
- Significant correlations between photopic negative response, afferent pupillary defect, and mean defects of visual fields in asymmetric optic nerve disorders.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- The photopic negative response of the Light-adapted 3.0 ERG in clinical settings.Documenta ophthalmologica. Advances in ophthalmology · 2020Article
- Optimizing a Portable ERG Device for Glaucoma Clinic: The Effect of Interstimulus Frequency on the Photopic Negative Response.Translational vision science & technology · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe photopic negative response (PhNR) may be useful as a tool to monitor longitudinal change in retinal ganglion cell (RGC) function. The goal was to assess PhNR test-retest reliability, and to estimate the amount of change between tests that is likely to be statistically significant for an individual test subject.
methodsPhotopic electroretinograms (ERGs) were recorded from 49 visually normal subjects (mean age, 38.9 years; range, 21-72 years). Signals were acquired using Dawson-Trick-Litzkow (DTL) electrodes in response to red stimulus at four flash energies (0.5, 1, 2.25, 3 cd·s/m
resultsFlash energy of 1.00 cd·s/m
conclusionThe b-wave peak-to-PhNR trough amplitude produced the most reliable measurement. TRANSLATIONAL RELEVANCE: A relatively large magnitude of change in PhNR amplitude is required to make clinical inferences about changes in RGC function. Refinement to the technique of acquisition and/or processing of the PhNR is recommended to improve reliability.
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