ArticleAllergy, asthma & immunology research2014
Reference ranges and determinant factors for exhaled nitric oxide in a healthy korean elderly population.
Article in Allergy, asthma & immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Need for sex-stratified reference values for exhaled nitric oxide as biomarker in chronic cough.ERJ open research · 2024Article
- Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population.Tanaffos · 2021Article
- Perspectives on chronic cough in Korea.Journal of thoracic disease · 2020Review
- Reference Ranges and Determinant Factors for Fractional Exhaled Nitric Oxide in a Healthy Saudi Adult Population.Medical science monitor basic research · 2020Article
- Clinical Features of Chronic Obstructive Pulmonary Disease with High Fractional Exhaled Nitric Oxide.Tuberculosis and respiratory diseases · 2020Article
- Article
- Is asthma in the elderly different? Functional and clinical characteristics of asthma in individuals aged 65 years and older.Asthma research and practice · 2019Article
- Reference values of fractional excretion of exhaled nitric oxide among non-smokers and current smokers.BMC pulmonary medicine · 2017Article
- Cohort Profile: The Korean Genome and Epidemiology Study (KoGES) Consortium.International journal of epidemiology · 2017Article
- Clinical application of exhaled nitric oxide measurements in a korean population.Allergy, asthma & immunology research · 2015Review
- Reference ranges for induced sputum eosinophil counts in Korean adult population.Asia Pacific allergy · 2014Article
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Authors and funding
15 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeExhaled nitric oxide (NO) is a useful non-invasive biomarker for asthma diagnosis; however, the literature suggests that exhaled NO levels may be affected by demographic factors. The present analysis investigated determinant factors that present exhaled NO reference levels for Korean elderly adults.
methodsFor reference levels, we analyzed the baseline data of healthy adult participants in the Ansung cohort. The fraction of exhaled NO (FeNO) was measured by NIOX MINO®. The characterization of the subjects was performed through structured questionnaires, spirometry, and methacholine challenge tests. To validate the diagnostic utility of the determined reference levels, asthma patients were recruited from medical institutions for FeNO measurement.
resultsA total of 570 healthy subjects were analyzed (mean age, 59.9±12.3; male, 37.0%) for reference levels. FeNO levels significantly correlated with weight, height, body mass index, atopy, or forced expiratory volume in 1 second % predicted by simple linear regression analysis. Multiple linear regression analysis identified gender as an independent determinant for FeNO levels; subsequently, the reference values for FeNO were 18.2±10.6 ppb (5th to 95th percentile, 6.0 to 37.4 ppb) for males and 12.1±6.9 ppb (5th to 95th percentile, 2.5 to 27.0 ppb) for females. The diagnostic utility of FeNO reference levels was validated by receiver operating curve analysis (area under curve, 0.900 for males and 0.885 for females) for diagnosing asthma. The optimal cutoff values for the prediction of asthma were 30.5 ppb for males and 20.5 ppb for females.
conclusionsThe current analysis presented reference ranges and the diagnostic utility of FeNO levels for asthma in Korean elderly adults.
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