ArticleAllergy, asthma & immunology research2014
Novel genes in Human Asthma Based on a Mouse Model of Allergic Airway Inflammation and Human Investigations.
Article in Allergy, asthma & immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Single-Nucleotide Polymorphisms of IL-17 Gene Are Associated with Asthma Susceptibility in an Asian Population.Medical science monitor : international medical journal of experimental and clinical research · 2016Pooled it
- [The function of circular RNA-microRNA-messenger RNA immune regulatory network in childhood allergic asthma].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma.PeerJ · 2023Article
- Genetic variants in miR-145 gene are associated with the risk of asthma in Taiwan.Scientific reports · 2022Article
- Investigation of the Possible Role of Tie2 Pathway andFrontiers in genetics · 2020Article
- Association of stem cell factor gene expression with severity and atopic state in patients with bronchial asthma.Respiratory research · 2017Article
- Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis.Scientific reports · 2015Article
- Article
- Role of murine asthma model in discovering asthma susceptible genes.Allergy, asthma & immunology research · 2014Article
- Significant Association of Cyclin D1 Promoter Genotypes With Asthma Susceptibility in Taiwan.In vivo (Athens, Greece)Article
- Association ofIn vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBased on a previous gene expression study in a mouse model of asthma, we selected 60 candidate genes and investigated their possible roles in human asthma.
methodsIn these candidate genes, 90 SNPs were genotyped using MassARRAY technology from 311 asthmatic children and 360 healthy controls of the Hungarian (Caucasian) population. Moreover, gene expression levels were measured by RT PCR in the induced sputum of 13 asthmatics and 10 control individuals. t-tests, chi-square tests, and logistic regression were carried out in order to assess associations of SNP frequency and expression level with asthma. Permutation tests were performed to account for multiple hypothesis testing.
resultsThe frequency of 4 SNPs in 2 genes differed significantly between asthmatic and control subjects: SNPs rs2240572, rs2240571, rs3735222 in gene SCIN, and rs32588 in gene PPARGC1B. Carriers of the minor alleles had reduced risk of asthma with an odds ratio of 0.64 (0.51-0.80; P=7×10(-5)) in SCIN and 0.56 (0.42-0.76; P=1.2×10(-4)) in PPARGC1B. The expression levels of SCIN, PPARGC1B and ITLN1 genes were significantly lower in the sputum of asthmatics.
conclusionsThree potentially novel asthma-associated genes were identified based on mouse experiments and human studies.
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