Evidence map›Paper›PMID 25374666›Full record

ReviewF1000prime reports2014

Control systems and coordination protocols of the secretory pathway.

Alberto Luini, Gabriella Mavelli, Juan Jung, Jorge Cancino

Abstract readReview
In one paragraph

Review in F1000prime reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Selective Secretion of KDEL-Bearing Proteins: Mechanisms and Functions.Frontiers in cell and developmental biology · 2022
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alberto LuiniConsiglio Nazionale delle Ricerche (CNR), Istituto di Biochimica delle Proteine (IBP) Via Pietro Castellino 111, 80131 Napoli Italy ; Telethon Institute of Genetics and Medicine (TIGEM) Via Pietro Castellino 111, 80131 Napoli Italy.
Gabriella MavelliIstituto di Analisi dei Sistemi ed Informatica Antonio Ruberti, Consiglio Nazionale delle Ricerche Viale Manzoni 30, 00185 Roma Italy.
Juan JungIstituto di Ricovero e Cura a Carattere Scientifico-SDN 80143 Napoli Italy.
Jorge CancinoConsiglio Nazionale delle Ricerche (CNR), Istituto di Biochimica delle Proteine (IBP) Via Pietro Castellino 111, 80131 Napoli Italy ; Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas, Universidad Andrés Bello Quillota 980, 2520000 Viña del Mar Chile.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Like other cellular modules, the secretory pathway and the Golgi complex are likely to be supervised by control systems that support homeostasis and optimal functionality under all conditions, including external and internal perturbations. Moreover, the secretory apparatus must be functionally connected with other cellular modules, such as energy metabolism and protein degradation, via specific rules of interaction, or "coordination protocols". These regulatory devices are of fundamental importance for optimal function; however, they are generally "hidden" at steady state. The molecular components and the architecture of the control systems and coordination protocols of the secretory pathway are beginning to emerge through studies based on the use of controlled transport-specific perturbations aimed specifically at the detection and analysis of these internal regulatory devices.

Identifiers

PMID25374666
PMCPMC4191269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.