ArticleFrontiers in microbiology2014
Regulatory role of tetR gene in a novel gene cluster of Acidovorax avenae subsp. avenae RS-1 under oxidative stress.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 37 citations in OpenAlex.
- Genome sequences of pathogenic and non-pathogenic Pantoea ananatis strains in maize (Zea mays L.).Access microbiology · 2025Article
- Strain-Specific Infection of Phage AP1 to Rice Bacterial Brown Stripe PathogenPlants (Basel, Switzerland) · 2024Article
- Genome Sequence and Adaptation Analysis of the Human and Rice Pathogenic StrainPathogens (Basel, Switzerland) · 2021Article
- Transcriptome Analysis of Gluconobacter oxydans WSH-003 Exposed to Elevated 2-Keto-L-Gulonic Acid Reveals the Responses to Osmotic and Oxidative Stress.Applied biochemistry and biotechnology · 2021Article
- Rotavirus infection induces glycan availability to promote ileum-specific changes in the microbiome aiding rotavirus virulence.Gut microbes · 2020Article
- Article
- Inhibitory Effect of Camptothecin against Rice Bacterial Brown Stripe Pathogen Acidovorax avenae subsp. avenae RS-2.Molecules (Basel, Switzerland) · 2016Article
- New insights into virulence mechanisms of rice pathogen Acidovorax avenae subsp. avenae strain RS-1 following exposure to ß-lactam antibiotics.Scientific reports · 2016Article
- Genome Sequence ofFrontiers in microbiology · 2016Article
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9 authors at 4 institutions in 3 countries.
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Abstract
Acidovorax avenae subsp. avenae is the causal agent of bacterial brown stripe disease in rice. In this study, we characterized a novel horizontal transfer of a gene cluster, including tetR, on the chromosome of A. avenae subsp. avenae RS-1 by genome-wide analysis. TetR acted as a repressor in this gene cluster and the oxidative stress resistance was enhanced in tetR-deletion mutant strain. Electrophoretic mobility shift assay demonstrated that TetR regulator bound directly to the promoter of this gene cluster. Consistently, the results of quantitative real-time PCR also showed alterations in expression of associated genes. Moreover, the proteins affected by TetR under oxidative stress were revealed by comparing proteomic profiles of wild-type and mutant strains via 1D SDS-PAGE and LC-MS/MS analyses. Taken together, our results demonstrated that tetR gene in this novel gene cluster contributed to cell survival under oxidative stress, and TetR protein played an important regulatory role in growth kinetics, biofilm-forming capability, superoxide dismutase and catalase activity, and oxide detoxicating ability.
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