ArticleFrontiers in human neuroscience2014
Is there a neuroanatomical basis of the vulnerability to suicidal behavior? A coordinate-based meta-analysis of structural and functional MRI studies.
Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- Altered Neural Activity in Adolescent Major Depressive Disorder With Nonsuicidal Self-Injury: A Resting-State Functional Magnetic Resonance Imaging Meta-Analysis.Neural plasticity · 2025Pooled it
- Functional alterations of the suicidal brain: a coordinate-based meta-analysis of functional imaging studies.Brain imaging and behavior · 2022Pooled it
- Joint and distinct neural structure and function deficits in major depressive disorder with suicidality: a multimodal meta-analysis of MRI studies.Journal of psychiatry & neuroscience : JPNPooled it
- Placebo aiTBS attenuates suicidal ideation and frontopolar cortical perfusion in major depression.Translational psychiatry · 2019Trial
- Biological Risk Factors for Suicidal Behavior in Children and Adolescents: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Gender differences in gray matter volume of the anterior cingulate cortex and suicidal ideation in patients with major depressive disorder: evidence from the REST-meta-MDD project.Translational psychiatry · 2025Article
- Comprehensive view of suicide: A neuro-immune-endocrine approach.World journal of psychiatry · 2025Review
- Structural brain changes in the anterior cingulate cortex of major depressive disorder individuals with suicidal ideation: Evidence from the REST-meta-MDD project.Psychological medicine · 2025Article
- Divergent suicidal symptomatic activations converge on somato-cognitive action network in depression.Molecular psychiatry · 2024Article
- Tryptophan and Substance Abuse: Mechanisms and Impact.International journal of molecular sciences · 2023Review
- Increased pituitary adenylate cyclase-activating peptide genes expression in the prefrontal cortex in schizophrenia in relation to suicide.Frontiers in molecular neuroscience · 2023Article
- The amplitude of low-frequency fluctuation characteristics in depressed adolescents with suicide attempts: a resting-state fMRI study.Frontiers in psychiatry · 2023Article
- Neuroimaging alterations of the suicidal brain and its relevance to practice: an updated review of MRI studies.Frontiers in psychiatry · 2023Review
- Functional connectivity of the amygdala and the antidepressant and antisuicidal effects of repeated ketamine infusions in major depressive disorder.Frontiers in neuroscience · 2023Article
- Brain grey and white matter structural associations withJCPP advances · 2022Article
- Diffusion tensor imaging studies on subjects with suicidal thoughts and behaviors: A descriptive literature review.Brain and behavior · 2022Review
- Identifying Changes of Brain Regional Homogeneity and Cingulo-Opercular Network Connectivity in First-Episode, Drug-Naïve Depressive Patients With Suicidal Ideation.Frontiers in neuroscience · 2022Article
- Childhood Maltreatment, Emotional Response Inhibition, and Suicide in Psychiatric Inpatients.Behavior therapy · 2021Article
- Multimodal Elements of Suicidality Reduction After Transcranial Magnetic Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2021Article
- Multimodal Neuroimaging of Suicidal Thoughts and Behaviors in a U.S. Population-Based Sample of School-Age Children.The American journal of psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe conducted meta-analyses of functional and structural neuroimaging studies comparing adolescent and adult individuals with a history of suicidal behavior and a psychiatric disorder to psychiatric controls in order to objectify changes in brain structure and function in association with a vulnerability to suicidal behavior.
methodsMagnetic resonance imaging studies published up to July 2013 investigating structural or functional brain correlates of suicidal behavior were identified through computerized and manual literature searches. Activation foci from 12 studies encompassing 475 individuals, i.e., 213 suicide attempters and 262 psychiatric controls were subjected to meta-analytical study using anatomic or activation likelihood estimation (ALE).
resultActivation likelihood estimation revealed structural deficits and functional changes in association with a history of suicidal behavior. Structural findings included reduced volumes of the rectal gyrus, superior temporal gyrus and caudate nucleus. Functional differences between study groups included an increased reactivity of the anterior and posterior cingulate cortices. DISCUSSION: A history of suicidal behavior appears to be associated with (probably interrelated) structural deficits and functional overactivation in brain areas, which contribute to a decision-making network. The findings suggest that a vulnerability to suicidal behavior can be defined in terms of a reduced motivational control over the intentional behavioral reaction to salient negative stimuli.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.