ReviewFrontiers in systems neuroscience2014
The contribution of hypothalamic macroglia to the regulation of energy homeostasis.
Review in Frontiers in systems neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance.Autophagy · 2020Article
- Review
- Circulating HDL levels control hypothalamic astrogliosis via apoA-I.Journal of lipid research · 2018Article
- PI3K signaling: A molecular pathway associated with acute hypophagic response during inflammatory challenges.Molecular and cellular endocrinology · 2016Review
- The role of tanycytes in hypothalamic glucosensing.Journal of cellular and molecular medicine · 2015Review
- Plasticity of the Melanocortin System: Determinants and Possible Consequences on Food Intake.Frontiers in endocrinology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypothalamus is critical for the regulation of energy homeostasis. Genetic and pharmacologic studies have identified a number of key hypothalamic neuronal circuits that integrate signals controlling food intake and energy expenditure. Recently, studies have begun to emerge demonstrating a role for non-neuronal cell types in the regulation of energy homeostasis. In particular the potential importance of different glial cell types is increasingly being recognized. A number of studies have described changes in the activity of hypothalamic macroglia (principally astrocytes and tanycytes) in response to states of positive and negative energy balance, such as obesity and fasting. This article will review these studies and discuss how these findings are changing our understanding of the cellular mechanisms by which energy homeostasis is regulated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.