ArticleIntestinal research2014
Long-Term Clinical Outcome of Clostridium difficile Infection in Hospitalized Patients: A Single Center Study.
Article in Intestinal research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The exploitation of nutrient metals by bacteria for survival and infection in the gut.PLoS pathogens · 2025Review
- Global, regional, and national burdens ofMicrobiology spectrum · 2025Article
- Fecal microbiota composition is a better predictor of recurrent Clostridioides difficile infection than clinical factors in a prospective, multicentre cohort study.BMC infectious diseases · 2024Observational
- Review of the Impact of Biofilm Formation on RecurrentMicroorganisms · 2023Review
- The evaluation of fecal microbiota transplantation vs vancomycin in a Clostridioides difficile infection model.Applied microbiology and biotechnology · 2022Article
- RBX7455, a Non-frozen, Orally Administered Investigational Live Biotherapeutic, Is Safe, Effective, and Shifts Patients' Microbiomes in a Phase 1 Study for Recurrent Clostridioides difficile Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Fecal Microbiota Transplantation May Be the Best Option in Treating Multiple Clostridioides difficile Infection: A Network Meta-Analysis.Infectious diseases and therapy · 2021Article
- External validation of two prediction tools for patients at risk for recurrentTherapeutic advances in gastroenterology · 2021Article
- Epidemiology of community-acquired and recurrentTherapeutic advances in gastroenterology · 2021Review
- Review
- RecurrentGut and liver · 2019Review
- Retrospective analysis of long-term gastrointestinal symptoms after Clostridium difficile infection in a nonelderly cohort.PloS one · 2018Article
- Rapid and accurate diagnosis ofIntestinal research · 2018Article
- Proton Pump Inhibitors Should be Used with Caution in Critically Ill Patients to Prevent the Risk of Clostridium difficile Infection.Gut and liver · 2016Article
- Risk of Clostridium difficile Infection with the Use of a Proton Pump Inhibitor for Stress Ulcer Prophylaxis in Critically Ill Patients.Gut and liver · 2016Article
- Incidence and Clinical Outcomes of Clostridium difficile Infection after Treatment with Tuberculosis Medication.Gut and liver · 2016Article
- Risk Factors for Delayed Recurrence of Clostridium difficile Infection.Intestinal research · 2014Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsAntibiotic usage and increasingly aging populations have led to increased incidence of Clostridium difficile infection (CDI) in worldwide. Recent studies in Korea have also reported increasing CDI incidence; however, there have been no reports on the long-term outcomes of CDI. We therefore investigated the long-term clinical outcomes of patients with CDI, including delayed recurrence, associated risk factors and mortality.
methodsHospitalized patients diagnosed with CDI at Seoul Paik Hospital between January 2007 and December 2008 were included. Their medical records were retrospectively investigated. 'Delayed recurrence' was defined as a relapse 8 weeks after a successful initial treatment. Multivariate logistic regression analysis was performed to identify risk factors for the delayed recurrence. Kaplan-Meier curves were used to analyze mortality rates.
resultsA total of 120 patients were enrolled; among them, 87 were followed-up for at least 1 year, with a mean follow-up period of 34.1±25.1 months. Delayed recurrence was observed in 17 patients (19.5%), and significant risk factors were age (over 70 years, P=0.049), nasogastric tube insertion (P=0.008), and proton pump inhibitor or H2-blocker treatments (P=0.028). The 12- and 24-month mortality rates were 24.6% and 32.5%, respectively. No deaths were directly attributed to CDI.
conclusionsDelayed recurrence of CDI was not rare, occurring in 19.5% of the study population. Although CDI-related mortality was not reported, 2-year (32.5%) mortality rate of CDI patients implies that a CDI diagnosis may predict severe morbidity and poor prognosis of the underlying disease.
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