ArticleCell reports2014
In vivo tissue-wide synchronization of mitochondrial metabolic oscillations.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Delay Differential Equation Approach to Oligomerization Reveals the Delay Dynamics Underlying Oscillations in Mitochondrial Fission.Bulletin of mathematical biology · 2026Article
- Bridging single cells to organs: Mesoscale modules as fundamental units of tissue function.Cell · 2025Review
- Longitudinal Imaging of the Premalignant Tumor Microenvironment Reveals Transient Myeloid States Predictive of Tumor Fate.bioRxiv : the preprint server for biology · 2025Article
- Life in the fast lane: Functional consequences of male-female dynamic differences in the renal auto-regulation of flow.bioRxiv : the preprint server for biology · 2025Article
- Article
- Intravital imaging of muscle damage and response to therapy in a model of Pompe disease.Clinical and translational medicine · 2024Article
- Damage-evoked signals in cochlear neurons and supporting cells.Frontiers in neurology · 2024Review
- MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis.bioRxiv : the preprint server for biology · 2023Article
- MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis.PLoS genetics · 2023Article
- Imaging Neutrophil Migration in the Mouse Skin to Investigate Subcellular Membrane Remodeling Under Physiological Conditions.Journal of visualized experiments : JoVE · 2022Article
- Multiphoton intravital microscopy of rodents.Nature reviews. Methods primers · 2022Article
- Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.PLoS biology · 2021Article
- The social nature of mitochondria: Implications for human health.Neuroscience and biobehavioral reviews · 2021Review
- Modeling Cell Energy Metabolism as Weighted Networks of Non-autonomous Oscillators.Frontiers in physiology · 2020Article
- Dynamics of the mitochondrial permeability transition pore: Transient and permanent opening events.Archives of biochemistry and biophysics · 2019Article
- Mitochondrial Populations Exhibit Differential Dynamic Responses to Increased Energy Demand during Exocytosis In Vivo.iScience · 2019Article
- In-vivo correlations between skin metabolic oscillations and vasomotion in wild-type mice and in a model of oxidative stress.Scientific reports · 2019Article
- Methods for imaging mammalian mitochondrial morphology: A prospective on MitoGraph.Analytical biochemistry · 2018Article
- Assessing Spatiotemporal and Functional Organization of Mitochondrial Networks.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Mitochondrial function in hypoxic ischemic injury and influence of aging.Progress in neurobiology · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Little is known about the spatiotemporal coordination of mitochondrial metabolism in multicellular organisms in situ. Using intravital microscopy in live animals, we report that mitochondrial metabolism undergoes rapid and periodic oscillations under basal conditions. Notably, mitochondria in vivo behave as a network of functionally coupled oscillators, which maintain a high level of coordination throughout the tissue via the activity of gap junctions. These findings reveal a unique aspect of the relationship between tissue architecture and self-organization of mitochondrial metabolism in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.