ArticleCell reports2014
Antivirulence properties of an antifreeze protein.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Microcurvature Controllable Metal-Organic Framework Nanoagents Capable of Ice-Lattice Matching for Cellular Cryopreservation.JACS Au · 2023Article
- Rickettsia helvetica infection is associated with microbiome modulation in Ixodes ricinus collected from humans in Serbia.Scientific reports · 2022Article
- Vector microbiota manipulation by host antibodies: the forgotten strategy to develop transmission-blocking vaccines.Parasites & vectors · 2022Review
- The Symbiotic Continuum Within Ticks: Opportunities for Disease Control.Frontiers in microbiology · 2022Review
- Grappling with the tick microbiome.Trends in parasitology · 2021Review
- Anti-Biofilm Molecules Targeting Functional Amyloids.Antibiotics (Basel, Switzerland) · 2021Review
- Host Response of Atlantic Salmon (Microorganisms · 2021Article
- IRF3 Signaling within the Mouse Stroma Influences Sepsis Pathogenesis.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Advances in the Study of the Tick Cattle Microbiota and the Influence on Vectorial Capacity.Frontiers in veterinary science · 2021Review
- Antifreeze Proteins and Their Practical Utilization in Industry, Medicine, and Agriculture.Biomolecules · 2020Review
- Resistance of Tick Gut Microbiome to Anti-Tick Vaccines, Pathogen Infection and Antimicrobial Peptides.Pathogens (Basel, Switzerland) · 2020Article
- Detection and Transstadial Passage ofHealthcare (Basel, Switzerland) · 2019Article
- Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission.Parasites & vectors · 2019Review
- A bite so sweet: the glycobiology interface of tick-host-pathogen interactions.Parasites & vectors · 2018Review
- Recent insights into the tick microbiome gained through next-generation sequencing.Parasites & vectors · 2018Review
- Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization.Nature communications · 2017Article
- From ice-binding proteins to bio-inspired antifreeze materials.Soft matter · 2017Review
- A Tick Antivirulence Protein Potentiates Antibiotics against Staphylococcus aureus.Antimicrobial agents and chemotherapy · 2017Article
- Pathogen-mediated manipulation of arthropod microbiota to promote infection.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Tick Bioactive Molecules as Novel Therapeutics: Beyond Vaccine Targets.Frontiers in cellular and infection microbiology · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
As microbial drug-resistance increases, there is a critical need for new classes of compounds to combat infectious diseases. The Ixodes scapularis tick antifreeze glycoprotein, IAFGP, functions as an antivirulence agent against diverse bacteria, including methicillin-resistant Staphylococcus aureus. Recombinant IAFGP and a peptide, P1, derived from this protein bind to microbes and alter biofilm formation. Transgenic iafgp-expressing flies and mice challenged with bacteria, as well as wild-type animals administered P1, were resistant to infection, septic shock, or biofilm development on implanted catheter tubing. These data show that an antifreeze protein facilitates host control of bacterial infections and suggest therapeutic strategies for countering pathogens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.