Evidence map›Paper›PMID 25373834›Full record

Trial reportJournal of general internal medicine2015

Clinicians' views and experiences of interventions to enhance the quality of antibiotic prescribing for acute respiratory tract infections.

Sibyl Anthierens, Sarah Tonkin-Crine, Jochen W Cals, Samuel Coenen, Lucy Yardley, Lucy Brookes-Howell, Patricia Fernandez-Vandellos, Jaroslaw Krawczyk, Maciek Godycki-Cwirko, Carl Llor and 6 more

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of general internal medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03265028 (National Implementation of a Multifaceted Web-based Communication Training to Reduce of Inappropriate Antibiotic Prescribing for), which is not on this map. Cited by 59 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 5 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03265028 completednot on this mapstarted 2017, after this paper: background citation

National Implementation of a Multifaceted Web-based Communication Training to Reduce of Inappropriate Antibiotic Prescribing for (Lower) Respiratory Tract Infections

Typeobservational_patient_registrySponsorUniversiteit AntwerpenRan2017 to 2018Enrolled15,802ConditionsRespiratory Tract InfectionsArmsTRACE e-learning
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 5 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Antibiotic prescribing for acute respiratory tract infections in primary care: an updated and expanded meta-ethnography.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018
    Pooled it
  6. Nasal sprays and a behavioural intervention for respiratory tract infections in primary care: 12-month follow-up of a randomised open-label trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026
    Trial
  7. Trial
  8. Rapid microbiological respiratory point-of-care testing: a qualitative study with primary care clinicians.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025
    Trial
  9. Cost-effectiveness analysis of procalcitonin and lung ultrasonography guided antibiotic prescriptions in primary care.The European journal of health economics : HEPAC : health economics in prevention and care · 2025
    Trial
  10. Implementation of the CHIldren with acute COugh (CHICO) intervention to improve antibiotics management: a qualitative study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024
    Trial
  11. Trial
  12. C-reactive protein-guided antibiotic prescribing for COPD exacerbations: a qualitative evaluation.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020
    Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 5 countries.

Sibyl AnthierensDepartment of Primary Care and Interdisciplinary Care, University of Antwerp, Universiteitsplein 1, 2016, Wilrijk, Belgium, sibyl.anthierens@uantwerpen.be.
Sarah Tonkin-Crine
Jochen W Cals
Samuel Coenen
Lucy Yardley
Lucy Brookes-Howell
Patricia Fernandez-Vandellos
Jaroslaw Krawczyk
Maciek Godycki-Cwirko
Carl Llor
Christopher C Butler
Theo Verheij
Herman Goossens
Paul Little
Nick A Francis
GRACE/CHAMP INTRO team
University of Antwerp · BECochrane · GBMedical University of Lodz · PLUniversitat Jaume I · ESMaastricht University · NLUniversity Medical Center Utrecht · NLUniversity of Southampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence shows a high rate of unnecessary antibiotic prescriptions in primary care in Europe and the United States. Given the costs of widespread use and associated antibiotic resistance, reducing inappropriate use is a public health priority.

objectiveWe aimed to explore clinicians' experiences of training in communication skills and use of a patient booklet and/or a C-reactive protein (CRP) point-of-care test to reduce antibiotic prescribing for acute respiratory tract infections (RTIs).

designWe used a qualitative research approach, interviewing clinicians who participated in a randomised controlled trial (RCT) testing two contrasting interventions.

participantsGeneral practice clinicians in Belgium, England, The Netherlands, Poland, Spain and Wales participated in the study. APPROACH: Sixty-six semi-structured interviews were transcribed verbatim, translated into English where necessary, and analysed using thematic and framework analysis. KEY

resultsClinicians from all countries attributed benefits for themselves and their patients to using both interventions. Clinicians reported that the communication skills training and use of the patient booklet gave them greater confidence in addressing patient expectations for an antibiotic by providing answers to common questions and supporting the clinician's own explanations. Clinicians felt the booklet could be used for a variety of patients and for different types of infections. The CRP test was viewed as a tool to decrease diagnostic uncertainty, to support non-prescription decisions, and to reassure patients, but was only necessary when clinicians were uncertain about the need for antibiotics.

conclusionProviding clinicians with training and support tools for use in practice was received positively and was valued by clinicians across countries. Interventions seemed to have influenced behaviour by increasing clinician knowledge about illness severity and prescribing, increasing confidence in making non-prescribing decisions when antibiotics were unnecessary, and enabling clinicians to anticipate positive outcomes when making such decisions. Addressing such determinants of behaviour change enabled interventions to be relevant for clinicians working across different contexts.

Indexed as

Attitude of Health PersonnelAdultAnti-Bacterial AgentsDrug PrescriptionsDrug Resistance, MicrobialFemaleGeneral PractitionersHumansInternationalityMaleMiddle AgedPamphletsPatient Education as TopicQuality of Health CareRespiratory Tract InfectionsAnti-Bacterial Agents

Identifiers

PMID25373834
PMCPMC4370987
OpenAlexW2128453617

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.