ArticleInhalation toxicology2014
Computational modeling of nanoscale and microscale particle deposition, retention and dosimetry in the mouse respiratory tract.
Article in Inhalation toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed.
- Integrating in vitro aerosol characterization and cross-species PBPK modeling to predict human lung exposure of inhaled therapeutic proteins.International journal of pharmaceutics: X · 2026Article
- A quantitative framework for animal-to-human extrapolation of inhaled aerosols using species-specific respiratory dosimetry.Archives of toxicology · 2026Article
- Development of a Controlled-Dose Aerosol Challenge Method Using a Lung Fluid Quantitative Nebulizer.Microorganisms · 2026Article
- Formulation and clinical translation of inhalable nanomedicines for the treatment and prevention of pulmonary infectious diseases.Drug delivery and translational research · 2025Review
- Nanomedicines Targeting Metabolic Pathways in the Tumor Microenvironment: Future Perspectives and the Role of AI.Metabolites · 2025Review
- Impact of Canadian Wildfire-Emitted Particulate Matter on THP-1 Lung Macrophage Health and Function.Environmental science & technology · 2025Article
- The size distribution of nanoparticles emitted from advanced manufacturing devices impacts predicted carcinogenic potential.Frontiers in public health · 2025Article
- Physicochemical Characterization of the Particulate Matter in New Jersey/New York City Area, Resulting from the Canadian Quebec Wildfires in June 2023.Environmental science & technology · 2024Article
- MMP-3 mediates copper oxide nanoparticle-induced pulmonary inflammation and fibrosis.Journal of nanobiotechnology · 2024Article
- Impact of Wildfires on Cardiovascular Health.Circulation research · 2024Review
- Using particle dimensionality-based modeling to estimate lung carcinogenicity of 3D printer emissions.Journal of applied toxicology : JAT · 2024Article
- Effective density of inhaled environmental and engineered nanoparticles and its impact on the lung deposition and dosimetry.Particle and fibre toxicology · 2024Article
- Induction of a type 2 inflammatory chronic rhinosinusitis in C57BL/6 mice.Asia Pacific allergy · 2023Article
- Development of Dependence in Smokers and Rodents With Voluntary Nicotine Intake: Similarities and Differences.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Review
- MMP-3-mediated cleavage of OPN is involved in copper oxide nanoparticle-induced activation of fibroblasts.Particle and fibre toxicology · 2023Article
- Prolonged smoldering Douglas fir smoke inhalation augments respiratory resistances, stiffens the aorta, and curbs ejection fraction in hypercholesterolemic mice.The Science of the total environment · 2023Article
- Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5-week study in A/J mice.Journal of applied toxicology : JAT · 2022Article
- Macrophage-mediated tissue response evoked by subchronic inhalation of lead oxide nanoparticles is associated with the alteration of phospholipases C and cholesterol transporters.Particle and fibre toxicology · 2022Article
- Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis.Autophagy · 2022Article
- Use of micro-CT to determine tracheobronchial airway geometries in three strains of mice used in inhalation toxicology as disease models.Anatomical record (Hoboken, N.J. : 2007) · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Comparing effects of inhaled particles across rodent test systems and between rodent test systems and humans is a key obstacle to the interpretation of common toxicological test systems for human risk assessment. These comparisons, correlation with effects and prediction of effects, are best conducted using measures of tissue dose in the respiratory tract. Differences in lung geometry, physiology and the characteristics of ventilation can give rise to differences in the regional deposition of particles in the lung in these species. Differences in regional lung tissue doses cannot currently be measured experimentally. Regional lung tissue dosimetry can however be predicted using models developed for rats, monkeys, and humans. A computational model of particle respiratory tract deposition and clearance was developed for BALB/c and B6C3F1 mice, creating a cross-species suite of available models for particle dosimetry in the lung. Airflow and particle transport equations were solved throughout the respiratory tract of these mice strains to obtain temporal and spatial concentration of inhaled particles from which deposition fractions were determined. Particle inhalability (Inhalable fraction, IF) and upper respiratory tract (URT) deposition were directly related to particle diffusive and inertial properties. Measurements of the retained mass at several post-exposure times following exposure to iron oxide nanoparticles, micro- and nanoscale C60 fullerene, and nanoscale silver particles were used to calibrate and verify model predictions of total lung dose. Interstrain (mice) and interspecies (mouse, rat and human) differences in particle inhalability, fractional deposition and tissue dosimetry are described for ultrafine, fine and coarse particles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.