ArticleDevelopmental cell2014
A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
Article in Developmental cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- CITK modulates BRCA1 recruitment at DNA double strand breaks sites through HDAC6.Cell death & disease · 2025Article
- Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast.G3 (Bethesda, Md.) · 2022Article
- Molecular Link between DNA Damage Response and Microtubule Dynamics.International journal of molecular sciences · 2022Review
- Single-cell image analysis to explore cell-to-cell heterogeneity in isogenic populations.Cell systems · 2021Review
- Ends and middle: Global force balance and septum location in fission yeast.The European physical journal. E, Soft matter · 2020Article
- Centrobin plays a role in the cellular response to DNA damage.Cell cycle (Georgetown, Tex.) · 2019Article
- Systematic mapping of cell wall mechanics in the regulation of cell morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- From observing to predicting single-cell structure and function with high-throughput/high-content microscopy.Essays in biochemistry · 2019Review
- Recent advances in tissue imaging for cancer research.F1000Research · 2019Review
- A computational framework to study sub-cellular RNA localization.Nature communications · 2018Article
- Genomewide phenotypic analysis of growth, cell morphogenesis, and cell cycle events inMolecular systems biology · 2018Article
- Sharing and reusing cell image data.Molecular biology of the cell · 2018Article
- Screening and purification of natural products from actinomycetes that affect the cell shape of fission yeast.Journal of cell science · 2017Article
- The Image Data Resource: A Bioimage Data Integration and Publication Platform.Nature methods · 2017Article
- Big data mining powers fungal research: recent advances in fission yeast systems biology approaches.Current genetics · 2017Review
- A genome-wide screen to identify genes controlling the rate of entry into mitosis in fission yeast.Cell cycle (Georgetown, Tex.) · 2016Article
- Microtubule organization is determined by the shape of epithelial cells.Nature communications · 2016Article
- PHOCOS: inferring multi-feature phenotypic crosstalk networks.Bioinformatics (Oxford, England) · 2016Article
- Metadata management for high content screening in OMERO.Methods (San Diego, Calif.) · 2016Article
- Visualizing quantitative microscopy data: History and challenges.Critical reviews in biochemistry and molecular biology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Understanding cells as integrated systems requires that we systematically decipher how single genes affect multiple biological processes and how processes are functionally linked. Here, we used multiprocess phenotypic profiling, combining high-resolution 3D confocal microscopy and multiparametric image analysis, to simultaneously survey the fission yeast genome with respect to three key cellular processes: cell shape, microtubule organization, and cell-cycle progression. We identify, validate, and functionally annotate 262 genes controlling specific aspects of those processes. Of these, 62% had not been linked to these processes before and 35% are implicated in multiple processes. Importantly, we identify a conserved role for DNA-damage responses in controlling microtubule stability. In addition, we investigate how the processes are functionally linked. We show unexpectedly that disruption of cell-cycle progression does not necessarily affect cell size control and that distinct aspects of cell shape regulate microtubules and vice versa, identifying important systems-level links across these processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.