Evidence map›Paper›PMID 25373773›Full record

ArticleDevelopmental cell2014

Outside in: inversion of cell polarity controls epithelial lumen formation.

George E Davis, Ondine B Cleaver

Abstract readComment
In one paragraph

Article in Developmental cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Developments and Opportunities for 3D Bioprinted Organoids.International journal of bioprinting · 2021
    Review
  6. Article
  7. Article
  8. α5β1 integrin mediates pulmonary epithelial cyst formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2017
    Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

George E DavisDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA. Electronic address: davisgeo@health.missouri.edu.
Ondine B CleaverDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Funding

Molecular regulation of Rho and Ras family GTPase activity controls vascular lumen formation.R01HL126518 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI CLEAVER, ONDINE B, DAVIS, GEORGE E · 2015 to 2023
$3.1M
Blood vessel tubulogenesis: Rasip1-directed GTPase signaling and cell polarity.R01HL113498 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI CLEAVER, ONDINE B · 2012 to 2015
$1.7M
Endothelial Signals During OrganogenesisR01DK079862 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI CLEAVER, ONDINE B · 2007 to 2011
$1.5M
NHLBI NIH HHS R01 HL113498NHLBI NIH HHS R01 HL126518NIDDK NIH HHS R01 DK079862
6 · The paper itself

Abstract

Establishment of cell polarity is important for epithelial lumen formation, and the molecular mechanisms directing this process are only partially understood. In this issue of Developmental Cell, Bryant et al. (2014) show that disassembly, membrane translocation, and reassembly of podocalyxin complexes controls epithelial cell polarization and lumen formation in 3D matrices.

Indexed as

MorphogenesisOrganogenesisAnimalsCell PolarityEpithelial CellsHumans

Identifiers

PMID25373773
PMCPMC4373590

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.