Desmosomal hotspots, microtubule delivery, and cardiac arrhythmogenesis.

Robin M Shaw

Open access · bronzeAbstract readComment

In one paragraph

Article in Developmental cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

1.4field-weighted citation impact, top 17% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

Intracellular trafficking pathways of Cx43 gap junction channels.Biochimica et biophysica acta. Biomembranes · 2018
Review
The "tail" of Connexin43: An unexpected journey from alternative translation to trafficking.Biochimica et biophysica acta · 2016
Review
Connexin 43 and CaV1.2 Ion Channel Trafficking in Healthy and Diseased Myocardium.Circulation. Arrhythmia and electrophysiology · 2016
Review
Cardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic intervention.Trends in cardiovascular medicine · 2015
Review
Desmosome regulation and signaling in disease.Cell and tissue research · 2015
Review

4 · The record

Corrections and comments

Comment on
Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin-EB1 interactions.2014

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Robin M ShawCedars-Sinai Medical Center, Los Angeles, CA 90048, USA; University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: robin.shaw@cshs.org.

University of California, Los Angeles · US

Funding

Novel Mechanisms of Cardiac Ion Channel RegulationR01HL094414 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHAW, ROBIN M · 2009 to 2018

$3.6M

NHLBI NIH HHS R01 HL094414

6 · The paper itself

Abstract

Microtubules can target proteins such as Connexin43 to plasma membrane subdomains. Patel et al. (2014) now show that the structural desmosome complex participates in targeted trafficking of membrane components through interactions between the microtubule network and the N terminus of desmoplakin, a region that is a pathogenic mutation hotspot.

Indexed as

AnimalsArrhythmogenic Right Ventricular DysplasiaConnexin 43DesmoplakinsHumansMicrotubule-Associated ProteinsMicrotubulesConnexin 43DesmoplakinsMicrotubule-Associated Proteins

Identifiers

PMID25373772

DOI10.1016/j.devcel.2014.10.010

PMCPMC4620127

OpenAlexW2034563839

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.