Evidence map›Paper›PMID 25373770›Full record

ArticleEuropean radiology2015

Cell tracking using (19)F magnetic resonance imaging: technical aspects and challenges towards clinical applications.

Houshang Amiri, Mangala Srinivas, Andor Veltien, Mark J van Uden, I Jolanda M de Vries, Arend Heerschap

Abstract read
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In one paragraph

Article in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Review
  3. Polymeric (Poly(lactic-ACS omega · 2025
    Article
  4. Feasibility and optimization ofPhysics in medicine and biology · 2024
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Low-molecular-weight paramagneticMagma (New York, N.Y.) · 2019
    Article
  12. Article
  13. Article
  14. A Hyperfluorinated Hydrophilic Molecule for AqueousContrast media & molecular imaging · 2018
    Article
  15. Review
  16. Article
  17. Nanoparticles and clinically applicable cell tracking.The British journal of radiology · 2015
    Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Houshang AmiriDepartment of Radiology, Radboud University Medical Center, Geert Grootplein 10, 6500 HB, Nijmegen, The Netherlands, amiri.houshang@gmail.com.
Mangala Srinivas
Andor Veltien
Mark J van Uden
I Jolanda M de Vries
Arend Heerschap

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(19)F MRI is emerging as a new imaging technique for cell tracking. It is particularly attractive because of its potential for direct and precise cell quantification. The most important challenge towards in vivo applications is the sensitivity of the technique, i.e. the detection limit in a reasonable imaging time. Optimal sensitivity can be achieved with dedicated (19)F compounds together with specifically adapted hardware and acquisition methods. In this paper we introduce the (19)F MRI technique focusing on these key sensitivity issues and review the state-of-the-art of (19)F MRI and developments towards its clinical use. We calculate (19)F detection limits reported in preclinical cell and clinical (19)F drug studies in terms of tissue concentration in a 1 cm(3) voxel, as an alternate way to compare detection limits. We estimate that a tissue concentration of a few millimoles per litre (mM) of (19)F is required for a human study at a resolution of 1 cm(3).

Indexed as

Cell TrackingContrast MediaDiagnostic ImagingFluorine-19 Magnetic Resonance ImagingHumansMagnetic FieldsContrast Media

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.