Trial reportHuman genetics2015
Effects of enamel matrix genes on dental caries are moderated by fluoride exposures.
Trial report in Human genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Genetic Variants and Dental Caries Susceptibility: An Umbrella Review and Multilevel Meta-Analysis.Genes · 2026Pooled it
- Genes in the pathway of tooth mineral tissues and dental caries risk: a systematic review and meta-analysis.Clinical oral investigations · 2020Pooled it
- Mechanical Properties of Dental Enamel in Patients with Genetic Caries Susceptibility.International journal of molecular sciences · 2025Article
- Single-cell transcriptomics reveals a compartmentalized antiviral interferon response in the nasal epithelium of mice.Journal of virology · 2025Article
- AMELX gene association to early childhood caries in south-Indian children: a case-control study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
- [Overexpression of tuftelin and KLF-5 and its clinicopathological features in hepatitis B virus-related hepatocellular carcinoma].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024Article
- In silico screening of non-synonymous SNPs in human TUFT1 gene.Journal, genetic engineering & biotechnology · 2023Article
- Polymorphisms in genes expressed during amelogenesis and their association with dental caries: a case-control study.Clinical oral investigations · 2023Article
- Genome-Wide Analysis of Dental Caries Variability Reveals Genotype-by-Environment Interactions.Genes · 2023Article
- Association of genetic variants in enamel-formation genes with dental caries: A meta- and gene-cluster analysis.Saudi journal of biological sciences · 2021Article
- ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations.International journal of environmental research and public health · 2020Article
- Pilot GWAS of caries in African-Americans shows genetic heterogeneity.BMC oral health · 2019Article
- Human genes influence the interaction between Streptococcus mutans and host caries susceptibility: a genome-wide association study in children with primary dentition.International journal of oral science · 2019Article
- Importance of bicarbonate transport in pH control during amelogenesis - need for functional studies.Oral diseases · 2018Review
- Consortium-based genome-wide meta-analysis for childhood dental caries traits.Human molecular genetics · 2018Article
- Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children.Clinical oral investigations · 2018Article
- Exploring the genomic basis of early childhood caries: a pilot study.International journal of paediatric dentistry · 2018Article
- Redefining the Phenotype of Dental Caries.Caries research · 2018Article
- Precision Dentistry in Early Childhood: The Central Role of Genomics.Dental clinics of North America · 2017Review
- Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries.Journal of human genetics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 6 institutions in 1 country.
Funding
Abstract
Dental caries (tooth decay) is the most common chronic disease, worldwide, affecting most children and adults. Though dental caries is highly heritable, few caries-related genes have been discovered. We investigated whether 18 genetic variants in the group of non-amelogenin enamel matrix genes (AMBN, ENAM, TUFT1, and TFIP11) were associated with dental caries experience in 13 age- and race-stratified samples from six parent studies (N = 3,600). Linear regression was used to model genetic associations and test gene-by-fluoride interaction effects for two sources of fluoride: daily tooth brushing and home water fluoride concentration. Meta-analysis was used to combine results across five child and eight adult samples. We observed the statistically significant association of rs2337359 upstream of TUFT1 with dental caries experience via meta-analysis across adult samples (p < 0.002) and the suggestive association for multiple variants in TFIP11 across child samples (p < 0.05). Moreover, we discovered two genetic variants (rs2337359 upstream of TUFT1 and missense rs7439186 in AMBN) involved in gene-by-fluoride interactions. For each interaction, participants with the risk allele/genotype exhibited greater dental caries experience only if they were not exposed to the source of fluoride. Altogether, these results confirm that variation in enamel matrix genes contributes to individual differences in dental caries liability, and demonstrate that the effects of these genes may be moderated by protective fluoride exposures. In short, genes may exert greater influence on dental caries in unprotected environments, or equivalently, the protective effects of fluoride may obviate the effects of genetic risk alleles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.