ArticleJournal of experimental & clinical cancer research : CR2014
An ER-associated miRNA signature predicts prognosis in ER-positive breast cancer.
Article in Journal of experimental & clinical cancer research : CR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- TWIST1 Upregulation Is a Potential Target for Reversing Resistance to the CDK4/6 Inhibitor in Metastatic Luminal Breast Cancer Cells.International journal of molecular sciences · 2023Article
- Identification of Three Circulating MicroRNAs in Plasma as Clinical Biomarkers for Breast Cancer Detection.Journal of clinical medicine · 2022Article
- Review
- Identification of pyroptosis-related lncRNAs for constructing a prognostic model and their correlation with immune infiltration in breast cancer.Journal of cellular and molecular medicine · 2021Article
- Estradiol-driven metabolism in transwomen associates with reduced circulating extracellular vesicle microRNA-224/452.European journal of endocrinology · 2021Article
- miRNA Expression Profiles in Luminal A Breast Cancer-Implications in Biology, Prognosis, and Prediction of Response to Hormonal Treatment.International journal of molecular sciences · 2020Review
- Potential four‑miRNA signature associated with T stage and prognosis of patients with pancreatic ductal adenocarcinoma identified by co‑expression analysis.Molecular medicine reports · 2019Article
- Novel MicroRNA-Based Risk Score Identified by Integrated Analyses to Predict Metastasis and Poor Prognosis in Breast Cancer.Annals of surgical oncology · 2018Article
- Identification of potential prognostic microRNA biomarkers for predicting survival in patients with hepatocellular carcinoma.Cancer management and research · 2018Article
- A six-long non-coding RNAs signature as a potential prognostic marker for survival prediction of ER-positive breast cancer patients.Oncotarget · 2017Article
- Ixeris dentata (Thunb. Ex Thunb.) Nakai Extract Inhibits Proliferation and Induces Apoptosis in Breast Cancer Cells through Akt/NF-κB Pathways.International journal of molecular sciences · 2017Article
- Identification of a seven-miRNA signature as prognostic biomarker for lung squamous cell carcinoma.Oncotarget · 2016Article
- A panel of 13-miRNA signature as a potential biomarker for predicting survival in pancreatic cancer.Oncotarget · 2016Article
- Targeting microRNAs as key modulators of tumor immune response.Journal of experimental & clinical cancer research : CR · 2016Review
- Subpopulation Treatment Effect Pattern Plot (STEPP) analysis of Ki67 assay according to histology: prognostic relevance for resected early stage 'pure' and 'mixed' lobular breast cancer.Journal of experimental & clinical cancer research : CR · 2016Article
- Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis.Journal of experimental & clinical cancer research : CR · 2015Article
- Inhibition of MTA1 by ERα contributes to protection hepatocellular carcinoma from tumor proliferation and metastasis.Journal of experimental & clinical cancer research : CR · 2015Article
- Primitive sarcoma of the breast: new insight on the proper surgical management.Journal of experimental & clinical cancer research : CR · 2015Article
- ERRγ target genes are poor prognostic factors in Tamoxifen-treated breast cancer.Journal of experimental & clinical cancer research : CR · 2015Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast cancer patients with positive estrogen receptor (ER) have a better prognosis. However, no prognostic miRNA signature was reported in the ER-positive breast cancer. The aim of the study was to identify and assess the prognostic significance of a miRNA signature in ER-positive breast cancer.
methodsTwo cohorts from The Cancer Genome Atlas (TCGA) dataset were used as training (n =596) and testing set (n =319). Differential expression profiling was identified in the training set. And the prognostic value of the miRNA signature was then assessed in the two cohorts.
resultsA total of 14 miRNAs were observed to be associated with the status of ER by significance analysis of microarrays (SAM) in the training set. Patients were characterized as high score or low score group according to the calculated risk scores from each miRNA. And patients in high score group had worse overall survival compared with those in low score group both in the training and testing set.
conclusionsOur study revealed a miRNA signature including 14 miRNAs associated with ER status which could act as a prognostic marker in ER-positive breast cancer.
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