ArticleRadiation oncology (London, England)2014
Long-term outcomes of adjuvant radiotherapy after surgical resection of central neurocytoma.
Article in Radiation oncology (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Treatment of Central Neurocytoma.Cancers · 2025Article
- Outcome-associated factors in a molecularly defined cohort of central neurocytoma.Acta neuropathologica · 2025Article
- The clinical spectrum of central neurocytomas ranges from benign to leptomeningeal disseminating disease: a single institutional surgical series of 33 patients.Frontiers in surgery · 2025Article
- Molecular and clinical characterization of atypical central neurocytomas: implications for diagnosis and treatment strategies.Discover oncology · 2024Article
- Article
- Awake craniotomy in an adolescent patient with an extraventricular neurocytoma.BMJ case reports · 2023Article
- Central neurocytomas in children: Clinicopathologic features and long-term surgical outcomes.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Whole Exome Sequencing Identifies PHF14 Mutations in Neurocytoma and Predicts Responsivity to the PDGFR Inhibitor Sunitinib.Biomedicines · 2022Article
- Comparison of surgery with or without adjuvant radiotherapy in treating central neurocytoma: a single-center retrospective real-world study.Journal of neuro-oncology · 2022Article
- Clinical Outcomes and Prognostic Analysis of 101 Patients of Central Neurocytoma: A 10-Year Treatment Experience at a Single Institution.Frontiers in oncology · 2022Article
- Impact of Adjuvant Radiotherapy in Patients with Central Neurocytoma: A Multicentric International Analysis.Cancers · 2021Article
- The last decade's experience of management of central neurocytomas: Treatment strategies and new options.Surgical neurology international · 2021Article
- Intraventricular neuroepithelial tumors: surgical outcome, technical considerations and review of literature.BMC cancer · 2020Observational
- Long-term follow-up of lateral ventricular central neurocytoma treated with subtotal resection followed by concurrent chemoradiotherapy and add on chemotherapy - Case report from a Tertiary Kenyan Cancer Hospital.Surgical neurology international · 2020Article
- Individual Treatment Decisions for Central Neurocytoma.Frontiers in neurology · 2020Article
- Prognosis and treatment outcomes of central neurocytomas: clinical interrogation based on a single center experience.Journal of neuro-oncology · 2018Article
- Systematic Analysis of Clinical Outcomes Following Stereotactic Radiosurgery for Central Neurocytoma.Brain tumor research and treatment · 2017Review
- Article
- Central Neurocytoma: A Review of Clinical Management and Histopathologic Features.Brain tumor research and treatment · 2016Review
- Clinical outcome and prognostic factors for central neurocytoma: twenty year institutional experience.Journal of neuro-oncology · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe role of adjuvant radiotherapy for central neurocytomas (CNs) is not clear. Therefore, we aimed to examine the clinical outcomes of treating histologically confirmed CNs with adjuvant RT after surgical resection. MATERIAL AND
methodsSixty-three CN patients were retrospectively evaluated: 24 patients underwent gross total resection (GTR); 28, subtotal resection (STR); 9, partial resection (PR), and 2, biopsy (Bx). They underwent adjuvant RT after surgery (median dose, 54 Gy).
resultsThe median follow-up was 69 months (15-129 months). The 5-year overall survival (OS) and 5-year progression-free survival (PFS) were 94.4% and 95% after GTR + RT, 96.4% and 100% after STR + RT, and 100% and 90.9% after PR + RT. Only three patients had tumor recurrence: at the primary site at 30 and 24 months in two GTR + PR patients, and dissemination to the spinal cord at 75 months in one STR + RT patient. Thirty-eight (63.3%) patients experienced late neurotoxicity (28, grade 1; 7, grade 2; 3, grade 3). Short-term memory impairment was the most common toxicity.
conclusionsRT after incomplete resection (IR) led to OS and PFS comparable to those for GTR. Considering the excellent outcomes and limited late toxicity, adjuvant RT maybe a good option for CN patients who undergo IR.
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