ArticleThe Journal of cell biology1989
Association of gelsolin with actin filaments and cell membranes of macrophages and platelets.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 149 citations in OpenAlex.
- Photobiomodulation induces microvesicle release in human keratinocytes: PI3 kinase-dependent pathway role.Lasers in medical science · 2022Article
- Regulation of Mitochondrial Function by the Actin Cytoskeleton.Frontiers in cell and developmental biology · 2021Review
- Low Admission Plasma Gelsolin Concentrations Identify Community-acquired Pneumonia Patients at High Risk for Severe Outcomes.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases.Pediatric nephrology (Berlin, Germany) · 2019Review
- ATP competes with PIP2 for binding to gelsolin.PloS one · 2018Article
- Respiratory chain enzyme deficiency induces mitochondrial location of actin-binding gelsolin to modulate the oligomerization of VDAC complexes and cell survival.Human molecular genetics · 2017Article
- Proteomic study of the brackish water musselZoological studies · 2015Article
- Gelsolin in cerebrospinal fluid as a potential biomarker of epilepsy.Neurochemical research · 2011Article
- Role of zinc metallothionein-3 (ZnMt3) in epidermal growth factor (EGF)-induced c-Abl protein activation and actin polymerization in cultured astrocytes.The Journal of biological chemistry · 2011Article
- Identification of nitroxyl-induced modifications in human platelet proteins using a novel mass spectrometric detection method.Molecular & cellular proteomics : MCP · 2009Article
- Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency.Molecular biology of the cell · 2009Article
- Three-dimensional reconstruction of the membrane skeleton at the plasma membrane interface by electron tomography.The Journal of cell biology · 2006Article
- CapZ-lipid membrane interactions: a computer analysis.Theoretical biology & medical modelling · 2006Article
- Gelsolin binds to polyphosphoinositide-free lipid vesicles and simultaneously to actin microfilaments.The Biochemical journal · 2005Article
- Regulation of cell motility by tyrosine phosphorylated villin.Molecular biology of the cell · 2004Article
- Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells.The Journal of cell biology · 2001Article
- Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC.Oncogene · 2000Article
- The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Gelsolin modulates phospholipase C activity in vivo through phospholipid binding.The Journal of cell biology · 1997Article
- A large-conductance K+ channel that is inhibited by the cytoskeleton in the smooth muscle cell line DDT1 MF-2.The Journal of physiology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent evidence that polyphosphoinositides regulate the function of the actin-modulating protein gelsolin in vitro raises the possibility that gelsolin interacts with cell membranes. This paper reports ultrastructural immunohistochemical data revealing that gelsolin molecules localize with plasma and intracellular membranes, including rough endoplasmic reticulum, cortical vesicles and mitochondria of macrophages, and blood platelets. Anti-gelsolin gold also labeled the surface and interior of secondary lysosomes presumably representing plasma gelsolin ingested by these cells from the lung surface by endocytosis. Gelsolin molecules, visualized with colloidal gold in replicas of the cytoplasmic side of the substrate-adherent plasma membrane of mechanically unroofed and rapidly frozen and freeze-dried macrophages, associated with the ends of short actin filaments sitting on the cytoplasmic membrane surface. A generalized distribution of gelsolin molecules in thin sections of resting platelets rapidly became peripheral, and plasmalemma association increased following thrombin stimulation. At later times the distribution reverted to the cytoplasmic distribution of resting cells. These findings provide the first evidence for gelsolin binding to actin filament ends in cells and indicate that gelsolin functions in both cytoplasmic and membrane domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.