Trial reportThe Journal of clinical psychiatry2014
Impact of prenatal exposure to serotonin reuptake inhibitors or maternal major depressive disorder on infant developmental outcomes.
Trial report in The Journal of clinical psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00279370 (Antidepressant Use During Pregnancy), which is not on this map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Antidepressant Use During Pregnancy
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Cognitive performance in offspring of parents with severe mental illness: a meta-analysis.Psychological medicine · 2026Pooled it
- Cognitive Performance in First-Degree Relatives of Individuals With vs Without Major Depressive Disorder: A Meta-analysis.JAMA psychiatry · 2019Pooled it
- Pooled it
- A systematic review of maternal antidepressant use in pregnancy and short- and long-term offspring's outcomes.Archives of women's mental health · 2018Pooled it
- Safety in treatment: Classical pharmacotherapeutics and new avenues for addressing maternal depression and anxiety during pregnancy.Pharmacological reviews · 2025Review
- Psychiatric illness and pregnancy: A literature review.Heliyon · 2023Article
- Antidepressants use during pregnancy and child psychomotor, cognitive and language development at 2 years of age-Results from the 3D Cohort Study.Frontiers in pharmacology · 2023Article
- Selective Serotonin Reuptake Inhibitors (SSRIs) in Pregnancy: An Updated Review on Risks to Mother, Fetus, and Child.Current psychiatry reports · 2022Review
- Prenatal Drug Exposure in Children With a History of Neuropsychiatric Care: A Nested Case-Control Study.Frontiers in psychiatry · 2022Article
- Disentangling vulnerability, state and trait features of neurocognitive impairments in depression.Brain : a journal of neurology · 2020Article
- Fifty Years of Research on Prenatal Substances: Lessons Learned for the Opioid Epidemic.Adversity and resilience science · 2020Article
- The causal web of foetal alcohol spectrum disorders: a review and causal diagram.European child & adolescent psychiatry · 2020Review
- A common clinical conundrum: Antidepressant treatment of depression in pregnant women.Seminars in perinatology · 2020Review
- Psychotropic Treatment During Pregnancy: Research Synthesis and Clinical Care Principles.Journal of women's health (2002) · 2020Review
- SSRIs and SNRIs (SRI) in Pregnancy: Effects on the Course of Pregnancy and the Offspring: How Far Are We from Having All the Answers?International journal of molecular sciences · 2019Review
- Risk factors for hospitalizations associated with depression among women during the years around a birth: a retrospective cohort study.International journal of population data science · 2019Article
- Article
- Major depressive disorder during pregnancy: Psychiatric medications have minimal effects on the fetus and infant yet development is compromised.Development and psychopathology · 2018Article
- Fine Motor Differences and Prenatal Serotonin Reuptake Inhibitors Exposure.The Journal of pediatrics · 2016Article
- Depression and Anxiety During Pregnancy: Evaluating the Literature in Support of Clinical Risk-Benefit Decision-Making.Current psychiatry reports · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo examine the impact of prenatal exposure to both serotonin reuptake inhibitors (SRIs; during any trimester) and maternal major depressive disorder (MDD; by DSM-IV criteria) on infant functioning. We hypothesized that infants with prenatal exposure to SRIs or MDD would have lower psychomotor, mental, and behavioral scores compared with nonexposed infants.
methodThis longitudinal study included 166 mother-infant dyads: 68 with prenatal MDD/SRI (n = 41) or MDD/no SRI exposure (n = 27) and 98 nonexposed controls. Maternal depression and SRI exposure assessments were completed at or as near to 20, 30, and 36 prenatal weeks and 12, 26, 52, and 78 weeks postpartum as feasible. Infants were evaluated with the Bayley Scales of Infant Development, Second Edition, including the psychomotor (Psychomotor Development Index; PDI), cognitive (Mental Development Index; MDI), and behavioral (Behavioral Rating Scale; BRS) components. Study assessments occurred between 2003 and 2009.
resultsNeither prenatal exposure to MDD/SRI nor MDD/no SRI significantly impacted overall PDI, MDI, or BRS scores. However, we observed a significant SRI exposure by time interaction for the PDI (P = .038). MDD/SRI exposure was associated with lower PDI scores at 26 (mean = 97.0) and 52 weeks (mean = 92.9) compared with nonexposed infants (mean = 101.4 and 100.5). This difference was no longer significant at the 78-week assessment.
conclusionsConsistent with previous studies, we found no impact of prenatal MDD/SRI exposure on MDI scores. Less favorable PDI scores were observed in the first year; notably, these scores remained well within the normative range. The effects of prenatal MDD/SRI exposure on motor functioning may be transitory. A longitudinal pattern of poor developmental outcomes has not been established.
trial registrationClinicalTrials.gov identifier: NCT00279370.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.