Evidence map›Paper›PMID 25373092›Full record

ReviewMilitary medicine2014

Long-chain omega-3 fatty acids and optimization of cognitive performance.

Matthew F Muldoon, Christopher M Ryan, Jeffrey K Yao, Sarah M Conklin, Stephen B Manuck

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Military medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00663871 (BioBehavioral Studies of Cardiovascular Disease), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00663871 nacompletednot on this map

BioBehavioral Studies of Cardiovascular Disease

TypeinterventionalSponsorUniversity of PittsburghRan2008 to 2012Enrolled272ConditionsCardiovascular Diseases, Mood Disorders, InflammationArmsFish Oil, Soybean Oil (Placebo)
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Observational
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
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  15. Article
  16. Prenatal fish oil supplementation and early childhood development in the Upstate KIDS Study.Journal of developmental origins of health and disease · 2017
    Observational
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Matthew F MuldoonHeart and Vascular Institute, University of Pittsburgh School of Medicine, Old Engineering Hall, Room 506, University of Pittsburgh, Pittsburgh, PA 15260.
Christopher M RyanDepartment of Psychiatry, University of Pittsburgh School of Medicine, 3500 Fifth Avenue, Suite 106, Pittsburg, PA 15213.
Jeffrey K YaoVA Pittsburgh Healthcare System and Department of Psychiatry, University of Pittsburgh School of Medicine, 7180 Highland Drive, Building 13, Room 131, Pittsburg, PA 15206.
Sarah M ConklinDepartment of Psychology and Neuroscience, Allegheny College, 520 North Main Street, Meadville, PA 16335.
Stephen B ManuckBehavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Sennott Square, 3rd Floor, 210 South Bouquet Street, Pittsburgh, PA 15260.
University of Pittsburgh · USAllegheny College · USPittsburg State University · USVA Pittsburgh Healthcare System · US

Funding

Substrates of Threat and Reward Sensitivity and CVD RiskP01HL040962 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 1988 to 2022
$31.1M
EFFECTS OF OMEGA-3 FATTY ACIDS ON COGNITIVE PERFORMANCER01AT004699 · NCCIH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MULDOON, MATTHEW F · 2009 to 2012
$524k
NCCIH NIH HHS R01 AT004699NHLBI NIH HHS P01 HL040962
6 · The paper itself

Abstract

Low consumption of the omega-3 fatty acids, eicosapentaenoic and docosahexaenonic acids, is linked to delayed brain development and, in late life, increased risk for Alzheimer's disease. The current review focuses on cognitive functioning during midlife and summarizes available scientific evidence relevant to the hypothesis that adequate dietary consumption of the long-chain omega-3 fatty acids is necessary for optimal cognitive performance. Taken together, the findings suggest that raising the currently low consumption among healthy adults may improve some aspects of cognitive performance. Nonetheless, evidence from randomized clinical trials is comparatively sparse and leaves unclear: (a) whether such effects are clinically significant, (b) whether effects of eicosapentaenoic acid and DHA differ, (c) which dimensions of cognitive function are affected, (d) the dose-response relationships, or (e) the time course of the response. Clarification of these issues through both laboratory and clinical investigations is a priority given the broad implications for public health, as well as for military personnel and other positions of high performance demand and responsibility.

Indexed as

CognitionDocosahexaenoic AcidsDose-Response Relationship, DrugEicosapentaenoic AcidFatty Acids, Omega-3HumansNeuroprotective AgentsDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3Neuroprotective Agents

Identifiers

PMID25373092
PMCPMC4734634
OpenAlexW1930721683

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.