ArticleThe journal of physical chemistry. B2014
Irreversible catalyst activation enables hyperpolarization and water solubility for NMR signal amplification by reversible exchange.
Article in The journal of physical chemistry. B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 141 citations in OpenAlex.
- IrTMes - a stable SABRE catalyst for the hyperpolarization of [1-The Analyst · 2026Article
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- High HThe journal of physical chemistry letters · 2025Article
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- LC-Photo-CIDNP hyperpolarization of biomolecules bearing a quasi-isolated spin pair: Magnetic-Field dependence via a rapid-shuttling device.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2024Article
- Perfluorinated Iridium Catalyst for Signal Amplification by Reversible Exchange Provides Metal-Free Aqueous Hyperpolarized [1-Journal of the American Chemical Society · 2024Article
- Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-Journal of magnetic resonance open · 2023Article
- Water-Compatible and Recyclable Heterogeneous SABRE Catalyst for NMR Signal Amplification.JACS Au · 2023Article
- Real-Time Pyruvate Chemical Conversion Monitoring Enabled by PHIP.Journal of the American Chemical Society · 2023Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-Metabolites · 2023Article
- SABRE Hyperpolarization with up to 200 bar Parahydrogen in Standard and Quickly Removable Solvents.International journal of molecular sciences · 2023Article
- Hyperpolarizing DNA Nucleobases via NMR Signal Amplification by Reversible Exchange.Molecules (Basel, Switzerland) · 2023Article
- Metabolic Tumor Imaging with Rapidly Signal-Enhanced 1-Chemphyschem : a European journal of chemical physics and physical chemistry · 2023Article
- Catalyst-Free Aqueous Hyperpolarized [1-ACS sensors · 2022Article
- RapidAnalytical chemistry · 2022Article
- Selective Isotope Labeling and LC-Photo-CIDNP Enable NMR Spectroscopy at Low-Nanomolar Concentration.Journal of the American Chemical Society · 2022Article
- Analysis of Complex Mixtures by Chemosensing NMR UsingAccounts of chemical research · 2022Article
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- Advancing homogeneous catalysis for parahydrogen-derived hyperpolarisation and its NMR applications.Chemical science · 2022Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Activation of a catalyst [IrCl(COD)(IMes)] (IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene; COD = cyclooctadiene)] for signal amplification by reversible exchange (SABRE) was monitored by in situ hyperpolarized proton NMR at 9.4 T. During the catalyst-activation process, the COD moiety undergoes hydrogenation that leads to its complete removal from the Ir complex. A transient hydride intermediate of the catalyst is observed via its hyperpolarized signatures, which could not be detected using conventional nonhyperpolarized solution NMR. SABRE enhancement of the pyridine substrate can be fully rendered only after removal of the COD moiety; failure to properly activate the catalyst in the presence of sufficient substrate can lead to irreversible deactivation consistent with oligomerization of the catalyst molecules. Following catalyst activation, results from selective RF-saturation studies support the hypothesis that substrate polarization at high field arises from nuclear cross-relaxation with hyperpolarized (1)H spins of the hydride/orthohydrogen spin bath. Importantly, the chemical changes that accompanied the catalyst's full activation were also found to endow the catalyst with water solubility, here used to demonstrate SABRE hyperpolarization of nicotinamide in water without the need for any organic cosolvent--paving the way to various biomedical applications of SABRE hyperpolarization methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.