Trial reportPloS one2014
Altered resting-state amygdala functional connectivity after 36 hours of total sleep deprivation.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Trial
- Neurophysiological differences in the adolescent brain following a single night of restricted sleep - A 7T fMRI study.Developmental cognitive neuroscience · 2018Trial
- Altered Resting-State Amygdala Functional Connectivity after Real-Time fMRI Emotion Self-Regulation Training.BioMed research international · 2016Trial
- Divergent disruption of brain networks following total and chronic sleep loss: a longitudinal fMRI study.Sleep · 2026Article
- Circadian rest/activity rhythms and change in MRI-derived brain volumes: Differences by age in a cognitively healthy sample.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Local and network neural activations and their associations with sleep parameters during threat conditioning and extinction in persons with Generalized Anxiety Disorder with and without Insomnia Disorder.bioRxiv : the preprint server for biology · 2025Article
- Bright light exposure reduces negative affect and modulates EEG activity in sleep-deprived and well-rested adolescents.Frontiers in behavioral neuroscience · 2025Article
- Distinct effect of partial sleep deprivation associated with gray matter changes in young and old adults.Frontiers in aging neuroscience · 2025Article
- Common Neural Correlates for Subjective and Objective Sleepiness Indices: A Functional Connectivity Study.Nature and science of sleep · 2025Article
- Insomnia and creativity in Chinese adolescents: mediation through need for cognition.BMC psychology · 2024Article
- Socioeconomic factors, sleep timing and duration, and amygdala resting-state functional connectivity in children.Frontiers in psychiatry · 2024Article
- Enhanced amygdala-cingulate connectivity associates with better mood in both healthy and depressive individuals after sleep deprivation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The abnormal reward network associated with insomnia severity and depression in chronic insomnia disorder.Brain imaging and behavior · 2021Article
- Brain Connectivity and Symptom Changes After Transcranial Magnetic Stimulation in Patients With Borderline Personality Disorder.Frontiers in psychiatry · 2021Article
- Altered Hypothalamic Functional Connectivity Following Total Sleep Deprivation in Young Adult Males.Frontiers in neuroscience · 2021Article
- Altered Functional Connectivity in the Resting State Neostriatum After Complete Sleep Deprivation: Impairment of Motor Control and Regulatory Network.Frontiers in neuroscience · 2021Article
- Decreased Functional Connectivity in the Reward Network and Its Relationship With Negative Emotional Experience After Total Sleep Deprivation.Frontiers in neurology · 2021Article
- The relationship between biological and psychosocial risk factors and resting-state functional connectivity in 2-month-old Bangladeshi infants: A feasibility and pilot study.Developmental science · 2019Article
- Effects of Chronic Sleep Restriction on the Brain Functional Network, as Revealed by Graph Theory.Frontiers in neuroscience · 2019Article
- Regional cerebral hypoperfusion after acute sleep deprivation: A STROBE-compliant study of arterial spin labeling fMRI.Medicine · 2019Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesRecent neuroimaging studies have identified a potentially critical role of the amygdala in disrupted emotion neurocircuitry in individuals after total sleep deprivation (TSD). However, connectivity between the amygdala and cerebral cortex due to TSD remains to be elucidated. In this study, we used resting-state functional MRI (fMRI) to investigate the functional connectivity changes of the basolateral amygdala (BLA) and centromedial amygdala (CMA) in the brain after 36 h of TSD. MATERIALS AND
methodsFourteen healthy adult men aged 25.9 ± 2.3 years (range, 18-28 years) were enrolled in a within-subject crossover study. Using the BLA and CMA as separate seed regions, we examined resting-state functional connectivity with fMRI during rested wakefulness (RW) and after 36 h of TSD.
resultsTSD resulted in a significant decrease in the functional connectivity between the BLA and several executive control regions (left dorsolateral prefrontal cortex [DLPFC], right dorsal anterior cingulate cortex [ACC], right inferior frontal gyrus [IFG]). Increased functional connectivity was found between the BLA and areas including the left posterior cingulate cortex/precuneus (PCC/PrCu) and right parahippocampal gyrus. With regard to CMA, increased functional connectivity was observed with the rostral anterior cingulate cortex (rACC) and right precentral gyrus.
conclusionThese findings demonstrate that disturbance in amygdala related circuits may contribute to TSD psychophysiology and suggest that functional connectivity studies of the amygdala during the resting state may be used to discern aberrant patterns of coupling within these circuits after TSD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.