ArticleJournal of proteome research2014
Cellular responses associated with ROS production and cell fate decision in early stress response to iron limitation in the diatom Thalassiosira pseudonana.
Article in Journal of proteome research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Morphological, biochemical, and physiological responses of a mixed periphytic diatom community to single and concurrent exposure to elevated Fe and Hg levels.Protoplasma · 2026Article
- Chloroplast-mitochondria synergy modulates responses to iron limitation in twoISME communications · 2026Article
- Argon non-thermal plasma treatment promotes the development of rice (Oryza sativa L.) in saline alkali environments.Protoplasma · 2024Article
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- Structural Identification of Metalloproteomes in Marine Diatoms, an Efficient Algae Model in Toxic Metals Bioremediation.Molecules (Basel, Switzerland) · 2022Article
- Seasonal mixed layer depth shapes phytoplankton physiology, viral production, and accumulation in the North Atlantic.Nature communications · 2021Article
- Responses of Marine Diatom Skeletonema marinoi to Nutrient Deficiency: Programmed Cell Death.Applied and environmental microbiology · 2020Article
- Bioengineering of Microalgae: Recent Advances, Perspectives, and Regulatory Challenges for Industrial Application.Frontiers in bioengineering and biotechnology · 2020Review
- Article
- Quantitative Proteomic Analysis Reveals Novel Insights into Intracellular Silicate Stress-Responsive Mechanisms in the DiatomInternational journal of molecular sciences · 2019Article
- Article
- Disentangling thermal stress responses in a reef-calcifier and its photosymbionts by shotgun proteomics.Scientific reports · 2018Article
- Autoinhibitory sterol sulfates mediate programmed cell death in a bloom-forming marine diatom.Nature communications · 2017Article
- Responses of the marine diatom Thalassiosira pseudonana to changes in COScientific reports · 2017Article
- Article
- Chronic Iron Limitation Confers Transient Resistance to Oxidative Stress in Marine Diatoms.Plant physiology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Investigation of how diatoms cope with the rapid fluctuations in iron bioavailability in marine environments may facilitate a better understanding of the mechanisms underlying their ecological success, in particular their ability to proliferate rapidly during favorable conditions. In this study, using in vivo biochemical markers and whole-cell iTRAQ-based proteomics analysis, we explored the cellular responses associated with reactive oxygen species (ROS) production and cell fate decision during the early response to Fe limitation in the centric diatom Thalassiosira pseudonana. Fe limitation caused a significant decrease in Photosystem (PS) II photosynthetic efficiency, damage to the photosynthetic electron transport chain in PS I, and blockage of the respiratory chain in complexes III and IV, which could all result in excess ROS accumulation. The increase in ROS likely triggered programmed cell death (PCD) in some of the Fe-limited cells through synthesis of a series of proteins involved in the delicate balance between pro-survival and pro-PCD factors. The results provide molecular-level insights into the major strategies that may be employed by T. pseudonana in response to Fe-limitation: the reduction of cell population density through PCD to reduce competition for available Fe, the reallocation of intracellular nitrogen and Fe to ensure survival, and an increase in expression of antioxidant and anti-PCD proteins to cope with stress.
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Registered trials
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