ArticlePloS one2014
Possible influence of B chromosomes on genes included in immune response and parasite burden in Apodemus flavicollis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Host-Parasite Relationship-Nematode Communities in Populations of Small Mammals.Animals : an open access journal from MDPI · 2022Article
- B Chromosomes' Sequences in Yellow-Necked MiceLife (Basel, Switzerland) · 2021Article
- Canalization and developmental stability of the yellow-necked mouse (Apodemus flavicollis) mandible and cranium related to age and nematode parasitism.Frontiers in zoology · 2021Article
- Review
- Article
- The origin of B chromosomes in yellow-necked mice (Apodemus flavicollis)-Break rules but keep playing the game.PloS one · 2017Article
- Correction: Possible influence of B chromosomes on genes included in immune response and parasite burden in Apodemus flavicollis.PloS one · 2015Article
Corrections and comments
- Erratum issuedCorrection: Possible influence of B chromosomes on genes included in immune response and parasite burden in Apodemus flavicollis.2015 · Bijelic-Cabrilo, Olivera [corrected to Bjelic-Cabrilo, Olivera]
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic background underlying wild populations immune response to different parasites is still not well understood. We studied immune response to multiple infections and to competition between different parasite species at different developmental stages in population of yellow-necked mouse, Apodemus flavicollis. Quantitative real-time PCR was used to investigate associations of MHC II-DRB, IL-10 and Tgf-β genes expressions with presence of intestinal parasites at different developmental stages. Furthermore, we were interested whether the host related characteristics (sex, age, body condition, presence of B chromosomes or expression of other genes) or characteristics of present parasites (number of adult parasites of each identified species, egg count of each parasite genus, total number of nematode individuals) affect differential expression of the studied genes. A significant invert association between the expression of MHC II-DRB and Tgf-β gene was found, which together with absence of IL-10 association confirmed modified Th2 as the main type of immune response to nematode infections. Effect of recorded parasites and parasite life-cycle stage on expression levels of MHC II-DRB gene was detected only through interactions with host-related characteristics such as sex, age, and the presence of B chromosomes. The presence of B chromosomes is associated with lower expression level of Tgf-β gene. Although the influence of host genetic background on parasite infection has already been well documented, this is the first study in mammals that gave presence of B chromosomes on immune response full consideration.
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