ArticleThe journal of physical chemistry. B2015
Identification of ubiquinol binding motifs at the Qo-site of the cytochrome bc1 complex.
Article in The journal of physical chemistry. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bcFEBS open bio · 2026Review
- Article
- CryoEM Structures of Native Quinol-Dependent Nitric Oxide Reductase in Resting and Quinol-Bound States.ACS bio & med chem Au · 2026Article
- Flexibility and Hydration of the QJournal of chemical information and modeling · 2025Article
- Different receptor models show differences in ligand binding strength and location: a computational drug screening for the tick-borne encephalitis virus.Molecular diversity · 2025Article
- The cytochrome bPhotosynthesis research · 2024Review
- CoQAntioxidants (Basel, Switzerland) · 2024Review
- Catalytic Reactions and Energy Conservation in the CytochromeChemical reviews · 2021Review
- Theoretical Description of the Primary Proton-Coupled Electron Transfer Reaction in the CytochromeJournal of the American Chemical Society · 2021Article
- Modeling the Energy Landscape of Side Reactions in the Cytochrome bcFrontiers in chemistry · 2021Article
- Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I.Frontiers in chemistry · 2019Article
- Article
- The unique fold and lability of the [2Fe-2S] clusters of NEET proteins mediate their key functions in health and disease.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018Review
- Autoantibody Profiling in Lupus Patients using Synthetic Nucleic Acids.Scientific reports · 2018Article
- Glutamate Water Gates in the Ion Binding Pocket of NaScientific reports · 2017Article
- Mechanism of the Primary Charge Transfer Reaction in the Cytochrome bcThe journal of physical chemistry. B · 2016Article
- Synthetic oligonucleotide antigens modified with locked nucleic acids detect disease specific antibodies.Scientific reports · 2016Article
- Atomistic determinants of co-enzyme Q reduction at the QScientific reports · 2016Article
- Atomic Detail Visualization of Photosynthetic Membranes with GPU-Accelerated Ray Tracing.Parallel computing · 2016Article
- Distinct properties of semiquinone species detected at the ubiquinol oxidation Qo site of cytochrome bc1 and their mechanistic implications.Journal of the Royal Society, Interface · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Enzymes of the bc1 complex family power the biosphere through their central role in respiration and photosynthesis. These enzymes couple the oxidation of quinol molecules by cytochrome c to the transfer of protons across the membrane, to generate a proton-motive force that drives ATP synthesis. Key for the function of the bc1 complex is the initial redox process that involves a bifurcated electron transfer in which the two electrons from a quinol substrate are passed to different electron acceptors in the bc1 complex. The electron transfer is coupled to proton transfer. The overall mechanism of quinol oxidation by the bc1 complex is well enough characterized to allow exploration at the atomistic level, but details are still highly controversial. The controversy stems from the uncertain binding motifs of quinol at the so-called Qo active site of the bc1 complex. Here we employ a combination of classical all atom molecular dynamics and quantum chemical calculations to reveal the binding modes of quinol at the Qo-site of the bc1 complex from Rhodobacter capsulatus. The calculations suggest a novel configuration of amino acid residues responsible for quinol binding and support a mechanism for proton-coupled electron transfer from quinol to iron-sulfur cluster through a bridging hydrogen bond from histidine that stabilizes the reaction complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.