ArticlePloS one2014
The use of biologically related model (Eclipse) for the intensity-modulated radiation therapy planning of nasopharyngeal carcinomas.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Dosimetric and Radiobiological Impact of Flattening Filter-Free Beam and Dose Calculation Algorithm Using RapidArc Plans for Cervical Cancer Treatment.Precision radiation oncology · 2023Article
- Direct incorporation of patient-specific efficacy and toxicity estimates in radiation therapy plan optimization.Medical physics · 2022Article
- Research Goal-Driven Data Model and Harmonization for De-Identifying Patient Data in Radiomics.Journal of digital imaging · 2021Article
- De-Identification of Radiomics Data Retaining Longitudinal Temporal Information.Journal of medical systems · 2020Article
- Temporal lobe microstructural abnormalities in patients with nasopharyngeal carcinoma quantitatively evaluated by high-resolution DWI and DKI after concurrent chemoradiotherapy.Clinical and translational radiation oncology · 2020Article
- Using biologically based objectives to optimize boost intensity-modulated radiation therapy planning for brainstem tumors in dogs.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2020Article
- On the gEUD biological optimization objective for organs at risk in Photon Optimizer of Eclipse treatment planning system.Journal of applied clinical medical physics · 2018Article
- Three-dimensional dose prediction and validation with the radiobiological gamma index based on a relative seriality model for head-and-neck IMRT.Journal of radiation research · 2017Article
- An integrated strategy of biological and physical constraints in biological optimization for cervical carcinoma.Radiation oncology (London, England) · 2017Article
- Radiobiological Optimization in Lung Stereotactic Body Radiation Therapy: Are We Ready to Apply Radiobiological Models?Frontiers in oncology · 2017Review
- Paradigm Shift in Radiation Treatment Planning Over Multiple Treatment Modalities.Journal of medical physicsReview
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3 authors.
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Abstract
purposeIntensity-modulated radiation therapy (IMRT) is the most common treatment technique for nasopharyngeal carcinoma (NPC). Physical quantities such as dose/dose-volume parameters are used conventionally for IMRT optimization. The use of biological related models has been proposed and can be a new trend. This work was to assess the performance of the biologically based IMRT optimization model installed in a popular commercial treatment planning system (Eclipse) as compared to its dose/dose volume optimization model when employed in the clinical environment for NPC cases.
methodsTen patients of early stage NPC and ten of advanced stage NPC were selected for this study. IMRT plans optimized using biological related approach (BBTP) were compared to their corresponding plans optimized using the dose/dose volume based approach (DVTP). Plan evaluation was performed using both biological indices and physical dose indices such as tumor control probability (TCP), normal tissue complication probability (NTCP), target coverage, conformity, dose homogeneity and doses to organs at risk. The comparison results of the more complex advanced stage cases were reported separately from those of the simpler early stage cases.
resultsThe target coverage and conformity were comparable between the two approaches, with BBTP plans producing more hot spots. For the primary targets, BBTP plans produced comparable TCP for the early stage cases and higher TCP for the advanced stage cases. BBTP plans reduced the volume of parotid glands receiving doses of above 40 Gy compared to DVTP plans. The NTCP of parotid glands produced by BBTP were 8.0 ± 5.8 and 7.9 ± 8.7 for early and advanced stage cases, respectively, while those of DVTP were 21.3 ± 8.3 and 24.4 ± 12.8, respectively. There were no significant differences in the NTCP values between the two approaches for the serial organs.
conclusionsOur results showed that the BBTP approach could be a potential alternative approach to the DVTP approach for NPC.
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