ArticlePloS one2014
Malaria, schistosomiasis and soil transmitted helminth burden and their correlation with anemia in children attending primary schools in Kinshasa, Democratic Republic of Congo.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01722539 (Efficacy and Safety of Sulfadoxine-pyrimethamine or Sulfadoxine-pyrimethamine Plus Piperaquine Regimens Delivered Through Intermittent Preventive Treatment in Schoolchildren of Democratic Republic of Congo), which is not on this map. Cited by 33 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of Sulfadoxine-pyrimethamine or Sulfadoxine-pyrimethamine Plus Piperaquine Regimens Delivered Through Intermittent Preventive Treatment in Schoolchildren of Democratic Republic of Congo: A Randomised Control Trial
Who cites it
33 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Over-dispersion in malaria-schistosoma co-infection: insights from a meta-analytical approach and systematic review.Infectious diseases of poverty · 2026Pooled it
- Prevalence of Plasmodium falciparum coinfection with Schistosoma haematobium and Schistosoma mansoni among children in sub-Saharan Africa: a systematic review and meta-analysis.Malaria journal · 2026Pooled it
- Malaria and helminth co-infections in children living in endemic countries: A systematic review with meta-analysis.PLoS neglected tropical diseases · 2021Pooled it
- The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis.PLoS neglected tropical diseases · 2019Pooled it
- Pooled it
- Trial
- Prevalence of Anemia and Its Associated Factors Among Schoolchildren in Metu Town Attending Public Primary Schools, Southwest Ethiopia.Health science reports · 2026Article
- Liver and bladder morbidity in a Schistosoma mansoni and haematobium co-endemic area in the Democratic Republic of Congo.PLoS neglected tropical diseases · 2026Article
- Prevalence of malaria andParasite epidemiology and control · 2025Review
- Asymptomatic Malaria Infection and Hidden Parasitic Burden in Gabonese Schoolchildren: Unveiling Silent Co-Infections in Rural and Urban Settings.Tropical medicine and infectious disease · 2024Article
- Childhood undernutrition mediates the relationship between open defecation with anemia among Ethiopian children: a nationally representative cross-sectional study.BMC public health · 2024Article
- Article
- Schistosoma Infection Burden and Risk Factors among School-Aged Children in a Rural Area of the Democratic Republic of the Congo.Tropical medicine and infectious disease · 2023Article
- Assessing risk factors for malaria and schistosomiasis among children in Misungwi, Tanzania, an area of co-endemicity: A mixed methods study.PLOS global public health · 2023Article
- Infection of Plasmodium falciparum and helminths among school children in communities in Southern and Northern Ghana.BMC infectious diseases · 2021Article
- Epidemiology of Schistosoma mansoni infection in Ituri Province, north-eastern Democratic Republic of the Congo.PLoS neglected tropical diseases · 2021Article
- Co-infections and Comorbidities of Multiple Parasites and Hepatitis B Virus Infections in the Lowland Area of Western Ethiopia: Implications for Integrated Approaches.Journal of multidisciplinary healthcare · 2021Article
- Article
- Determinants of Helminthic Infections and Anemia among Schoolchildren in Bahir Dar Zuria District, Northwest Ethiopia.Journal of parasitology research · 2021Article
- Helminth infections among rural schoolchildren in Southern Ethiopia: A cross-sectional multilevel and zero-inflated regression model.PLoS neglected tropical diseases · 2020Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnaemia reduces cognitive potential in school children, retards their growth and predisposes them to other diseases. As there is a paucity of data on the current burden of P. falciparum, S. mansoni and soil transmitted helminths (STH) infections and their correlation with schoolchildren's anemia in the Democratic Republic of Congo (DRC), we collect these data.
methodsThis study reports baseline data collected from a randomized controlled trial investigating the impact of IPT with SP and SP-PQ on anemia and malaria morbidity in Congolese schoolchildren (Trial registration: NCT01722539; PACTR201211000449323). S. mansoni and STH infections were assessed using kato-katz technique. Malaria infection and hemoglobin concentration were assessed using Blood smear and Hemocontrol device, respectively.
resultsA total of 616 primary schoolchildren from 4 to 13 years old were enrolled in the study. The prevalence of Plasmodium spp. infection was 18.5% (95%CI:15.6-21.9). Amongst those infected, 24 (21%), 40 (35.1%), 40 (35.1%), 10 (8.8%), had light, moderate, heavy, very high malaria parasite density, respectively. Above 9 years of age (p = 0.02), male and history of fever (p = 0.04) were both associated with malaria infection. The overall prevalence of S. mansoni infection was 6.4% (95%CI:4.4-9.1). Girls were associated with S. mansoni infection (p = 0.04). T. trichiura was the most prevalent STH infection (26.3%), followed by A. lumbricoides (20.1%). Co-infection with malaria-S. mansoni and malaria-STH was, respectively, 1.5% (CI95%:0.7-3.3) and 6.4% (CI95% 4.4-9.1). The prevalence of anemia was found to be 41.6% (95%CI:37.7-45.6) and anemia was strongly related with Plasmodium ssp infection (aOR:4.1; CI95%:2.6-6.5;p<0.001) and S. mansoni infection (aOR:3.3;CI95%:1.4-7.8;p<0.01).
conclusionMalaria and S. mansoni infection were strongly associated with high prevalence of anemia in schoolchildren. Therefore, specific school-based interventions, such as intermittent preventive treatment or prophylaxis, LLITN distribution, anthelminthic mass treatment and micronutrient supplementation are needed to improve school children's health.
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