Evidence map›Paper›PMID 25372004›Full record

Trial reportBrazilian journal of physical therapy

Effect of a single session of transcranial direct-current stimulation on balance and spatiotemporal gait variables in children with cerebral palsy: A randomized sham-controlled study.

Luanda A C Grecco, Natália A C Duarte, Nelci Zanon, Manuela Galli, Felipe Fregni, Claudia S Oliveira

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brazilian journal of physical therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05670522 (Transcranial Direct Current Stimulation Versus Virtual Reality on Gait in Children With Spastic Diplegia), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05670522 nacompletednot on this map

Transcranial Direct Current Stimulation Versus Virtual Reality on Gait in Children With Spastic Diplegia

TypeinterventionalSponsorBeni-Suef UniversityRan2020 to 2021Enrolled40ConditionsCerebral PalsyArmsTranscranial direct current stimulation, Virtual reality
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  19. Transcranial Magnetic and Direct Current Stimulation in Children.Current neurology and neuroscience reports · 2017
    Review
  20. Transcranial direct current stimulation in children and adolescents: a comprehensive review.Journal of neural transmission (Vienna, Austria : 1996) · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luanda A C GreccoUniversidade Nove de Julho, São Paulo, SP, Brazil.
Natália A C DuarteUniversidade Nove de Julho, São Paulo, SP, Brazil.
Nelci ZanonCentro de Neurocirurgia Pediátrica, São Paulo, SP, Brazil.
Manuela GalliDipartimento di Bioingegneria, Politecnico di Milano, Milan, Italy.
Felipe FregniCenter of Clinical Research Learning, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA, United States.
Claudia S OliveiraUniversidade Nove de Julho, São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscranial direct-current stimulation (tDCS) has been widely studied with the aim of enhancing local synaptic efficacy and modulating the electrical activity of the cortex in patients with neurological disorders.

objectiveThe purpose of the present study was to determine the effect of a single session of tDCS regarding immediate changes in spatiotemporal gait and oscillations of the center of pressure (30 seconds) in children with cerebral palsy (CP).

methodA randomized controlled trial with a blinded evaluator was conducted involving 20 children with CP between six and ten years of age. Gait and balance were evaluated three times: Evaluation 1 (before the stimulation), Evaluation 2 (immediately after stimulation), and Evaluation 3 (20 minutes after the stimulation). The protocol consisted of a 20-minute session of tDCS applied to the primary motor cortex at an intensity of 1 mA. The participants were randomly allocated to two groups: experimental group - anodal stimulation of the primary motor cortex; and control group - placebo transcranial stimulation.

resultsSignificant reductions were found in the experimental group regarding oscillations during standing in the anteroposterior and mediolateral directions with eyes open and eyes closed in comparison with the control group (p<0.05). In the intra-group analysis, the experimental group exhibited significant improvements in gait velocity, cadence, and oscillation in the center of pressure during standing (p<0.05). No significant differences were found in the control group among the different evaluations.

conclusionA single session of tDCS applied to the primary motor cortex promotes positive changes in static balance and gait velocity in children with cerebral palsy.

Indexed as

Postural BalanceTranscranial Direct Current StimulationCerebral PalsyChildCross-Sectional StudiesDouble-Blind MethodHumansPhysical Therapy Modalities

Identifiers

PMID25372004
PMCPMC4228627

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.