Evidence map›Paper›PMID 25371688›Full record

ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2014

Nutritional supplementation with the mushroom Agaricus sylvaticus reduces oxidative stress in children with HIV.

Marcela S Figueira, Luana A Sá, Amanda S Vasconcelos, Danilo R Moreira, Paula Soc Laurindo, Danielle Rg Ribeiro, Rogério S Santos, Paulo Guzzo, Maria F Dolabela, Sandro Percario

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Marcela S FigueiraOxidative Stress Research Laboratory - Institute of Biological Sciences - Federal University of Para;
Luana A SáOxidative Stress Research Laboratory - Institute of Biological Sciences - Federal University of Para;
Amanda S VasconcelosOxidative Stress Research Laboratory - Institute of Biological Sciences - Federal University of Para;
Danilo R MoreiraOxidative Stress Research Laboratory - Institute of Biological Sciences - Federal University of Para;
Paula Soc LaurindoOxidative Stress Research Laboratory - Institute of Biological Sciences - Federal University of Para;
Danielle Rg RibeiroOxidative Stress Research Laboratory - Institute of Biological Sciences - Federal University of Para;
Rogério S SantosOxidative Stress Research Laboratory - Institute of Biological Sciences - Federal University of Para;
Paulo GuzzoSpecialized Reference Unit for Maternal & Adolescent Children (URE MIA);
Maria F DolabelaPharmacy Faculty, Institute of Health Sciences, Federal University of Para - Belém, Pará, Brazil.
Sandro PercarioOxidative Stress Research Laboratory - Institute of Biological Sciences - Federal University of Para;
Universidade Federal do Pará · BRUniversidade Federal do Oeste do Pará · BRChildren's Specialized Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe involvement of free radicals and oxidative stress in HIV infection has been extensively studied, and the benefits of antioxidant supplementation in animal studies have been demonstrated. However, few studies have demonstrated a benefit in clinical studies.

objectiveTo verify the effects of dietary supplementation with Agaricus sylvaticus, a mushroom rich in antioxidants, on the oxidative profile of children born with HIV undergoing antiretroviral therapy.

designThe sample included 24 children (both boys and girls) between two and eight years of age, of whom 10 were HIV positive and received supplementation with Agaricus sylvaticus for a three-month period, and 14 were HIV negative and received no supplementation. At the beginning and conclusion of the study, thiobarbituric acid-reactive substances (TBARS), nitrite and nitrate (NN), Trolox equivalent antioxidant capacity, and the antioxidant capacity of inhibition of diphenyl-picrilhidrazil (DPPH) free radicals were analyzed.

resultsBefore supplementation, significantly higher values of TBARS and NN, but decreased values of DPPH, were observed in infected subjects when compared with HIV-negative subjects. After supplementation, a reduction of TBARS and NN values and an increase in DPPH and Trolox equivalent antioxidant capacity values were observed in HIV-positive subjects.

conclusionsThe results of the present study suggest the involvement of oxidative stress in HIV infection, with the participation of NN synthesis. Additionally, supplementation reversed oxidative alterations and improved antioxidant defense in infected individuals, and may become a complementary strategy in the treatment of these patients.

Indexed as

Agaricus sylvaticusAntioxidantsAntiretroviral therapyChildrenHIVOxidative stress

Identifiers

PMID25371688
PMCPMC4211349
OpenAlexW2280566773

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.