Evidence map›Paper›PMID 25371663›Full record

ArticlePPAR research2014

The Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor Gamma Gene Modifies the Association of Physical Activity and Body Mass Changes in Polish Women.

Aleksandra Zarebska, Zbigniew Jastrzebski, Pawel Cieszczyk, Agata Leonska-Duniec, Katarzyna Kotarska, Mariusz Kaczmarczyk, Marek Sawczuk, Agnieszka Maciejewska-Karlowska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PPAR research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Clinical assessment for diet prescription.Journal of preventive medicine and hygiene · 2022
    Review
  6. Effects ofFrontiers in public health · 2022
    Article
  7. Does theJournal of human kinetics · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. TheJournal of sports science & medicine · 2016
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Aleksandra ZarebskaFaculty of Tourism and Recreation, Gdansk University of Physical Education and Sport, Kazimierza Gorskiego Street 1, 80-336 Gdansk, Poland.
Zbigniew JastrzebskiFaculty of Tourism and Recreation, Gdansk University of Physical Education and Sport, Kazimierza Gorskiego Street 1, 80-336 Gdansk, Poland.
Pawel CieszczykFaculty of Physical Education and Health Promotion, University of Szczecin, Piastow 40B, 71-065 Szczecin, Poland.
Agata Leonska-DuniecFaculty of Physical Education and Health Promotion, University of Szczecin, Piastow 40B, 71-065 Szczecin, Poland.
Katarzyna KotarskaFaculty of Physical Education and Health Promotion, University of Szczecin, Piastow 40B, 71-065 Szczecin, Poland.
Mariusz KaczmarczykFaculty of Physical Education and Health Promotion, University of Szczecin, Piastow 40B, 71-065 Szczecin, Poland.
Marek SawczukFaculty of Physical Education and Health Promotion, University of Szczecin, Piastow 40B, 71-065 Szczecin, Poland.
Agnieszka Maciejewska-KarlowskaFaculty of Physical Education and Health Promotion, University of Szczecin, Piastow 40B, 71-065 Szczecin, Poland.
University of Szczecin · PLGdansk University of Physical Education and Sport · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peroxisome proliferator-activated receptor γ is a key regulator of adipogenesis, responsible for fatty acid storage and maintaining energy balance in the human body. Studies on the functional importance of the PPARG Pro12Ala polymorphic variants indicated that the observed alleles may influence body mass measurements; however, obtained results were inconsistent. We have decided to check if body mass changes observed in physically active participants will be modulated by the PPARG Pro12Ala genotype. The genotype distribution of the PPARG Pro12Ala allele was examined in a group of 201 Polish women measured for selected body mass variables before and after the completion of a 12-week training program. The results of our experiment suggest that PPARG genotype can modulate training-induced body mass measurements changes: after completion of the training program, Pro12/Pro12 homozygotes were characterised by a greater decrease of body fat mass measurements in comparison with 12Ala allele carriers. These results indicate that the PPARG 12Ala variant may impair the training-induced positive effects on body mass measurements; however, the detailed mechanism of such interaction remained unclear and observed correlation between PPARG genotype and body mass differential effects should be interpreted with caution.

Identifiers

PMID25371663
PMCPMC4211145
OpenAlexW2158852900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.