Evidence map›Paper›PMID 25371567›Full record

ArticleAfrican journal of traditional, complementary, and alternative medicines : AJTCAM2014

Antioxidant activities in vitro and hepatoprotective effects of Nelumbo nucifera leaves in vivo.

Lin Yuan, Xuezhu Gu, Zhenhua Yin, Wenyi Kang

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Article in African journal of traditional, complementary, and alternative medicines : AJTCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Amphiphilic Bioactives of Freshwater Aquatic PlantsPharmaceuticals (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Phytochemical Profile and Biological Activity of Nelumbo nucifera.Evidence-based complementary and alternative medicine : eCAM · 2015
    Review
  6. Simultaneous determination of rutin, isoquercetin, and quercetin flavonoids inInternational journal of pharmaceutical investigation
    Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lin YuanInstitute of Chinese Materia, Henan University, Kaifeng 475004, China ; Chemical Science and Technology Department, Kunming University, Yunnan Kunming 650214, China.
Xuezhu GuInstitute of Chinese Materia Medica, Traditional Chinese Medical Research Institute, Beijing, 100700, China.
Zhenhua YinInstitute of Chinese Materia, Henan University, Kaifeng 475004, China.
Wenyi KangInstitute of Chinese Materia, Henan University, Kaifeng 475004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHerbal medicines played a major role in the treatment of hepatic disorders, and a number of medicinal plants and their compounds were widely used for the treatment of these disorders, and oxidant stress injury was one of the mechanism of liver injury. MATERIALS AND

methodsAntioxidant activity of Nelumbo nucifera leaves (NU) extracts was assayed by the methods of scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzo-thiazoline-6-sulfonicacid) (ABTS) radical and ferric reducing antioxidant power (FRAP) in vitro. By intraperitoneal injection carbon tetrachloride (CCl4) to establish acute liver injury model in mice, the levels of Glutamic-pyruvic transaminase (GPT), glutamic-oxaloacetic transaminase (GOT), superoxide dismutase (SOD) and the content of and maleicdialdehyde (MDA) were detected to evaluate hepatoprotective effect of NU using corresponding test kit.

resultsEtOAC (NUEA) and n-BuOH extracts (NUBU) of N. nucifera leaves had good scavenging DPPH and ABTS radical activity and ferric reducing antioxidant power in vitro. DPPH radical scavenging activity and ferric reducing antioxidant power of NUEA (IC50= 6.68±0.29 µg/mL, RACT50=1749.82±67.03 µmol/g) and NUBU (IC50= 4.61±0.01 µg/mL, RACT50=1995.27±135.71 µmol/g ) were higher than that of BHT (IC50=8.76±0.20 µg/mL, RACT50=1581.68±97.41 µmol/g) and Dangfeiliganning (IC50=28.06±0.17 µg/mL, RACT50=1028.55±3.28 µmol/g). ABTS radical scavenging activity of NUEA (IC50= 5.32±0.12 µg/mL) and NUBU (IC50= 8.16±0.27 µg/mL) were higher than that of Dangfeiliganning (IC50= 9.76±0.16 µg/mL). Thus, hepatoprotective effect of NUEA and NUBU was evaluated on CCl4-induced acute liver injury mice. The results showed that the levels of GOT and GPT in each treatment group significantly decreased (p<0.001 and p<0.01, p<0.05, respectively) except for the group of NUEA (130.8 mg/kg) (p>0.05). The contents of malondialdehyde (MDA) in liver in groups of NUEA (523 mg/kg), NUBU (840.5 and 420.5 mg/kg, repectively) had significant decrease (p<0.001 and p<0.05, respectively), and the level of SOD in liver for each treatment group could significantly decrease (p<0.001, p<0.05, respectively).

conclusionNUEA and NUBU had significantly hepatoprotective effect for Calcium tetrachloride CCl4-induced liver injury, which might be attributable to its antioxidant activity.

Indexed as

Alanine TransaminaseAldehydesAnimalsAntioxidantsAspartate AminotransferasesCarbon TetrachlorideChemical and Drug Induced Liver InjuryHumansLiverMaleMiceNelumboPhytotherapyPlant ExtractsPlant LeavesProtective AgentsAlanine TransaminaseAldehydesAntioxidantsAspartate AminotransferasesCarbon TetrachloridemalealdehydePlant ExtractsProtective AgentsAntioxidant activityCarbon tetrachloride (CCl4)hepatoprotective effectNelumbo nucifera leaves

Identifiers

PMID25371567
PMCPMC4202423

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.