ArticleThe Plant cell2014
High-resolution transcript profiling of the atypical biotrophic interaction between Theobroma cacao and the fungal pathogen Moniliophthora perniciosa.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- State of the Art of the Molecular Biology of the Interaction between Cocoa and Witches' Broom Disease: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Genomic and Transcriptomic Analyses Provide Insights Into Erysiphe necator Pathogenicity and Grapevine Response.Plant biotechnology journal · 2026Article
- Diversity of Endophytic Fungi in Theobroma grandiflorum and their Potential for Biological Control of Witches' Broom Disease and Promotion of Cupuaçu Seedling Growth in the Amazon.Current microbiology · 2026Article
- Chromosome-level comparative genomics and host-specific fungal transcriptomics uncover adaptive virulence strategies in the sugarcane smut pathogen.BMC genomics · 2025Article
- Integrative multi-omics approach identified emerging viral threat in Theobroma cacao plants.BMC plant biology · 2025Article
- Article
- Proteomic Analysis of Plants with Binding Immunoglobulin Protein Overexpression Reveals Mechanisms Related to Defense AgainstPlants (Basel, Switzerland) · 2025Article
- Apoplastomes of contrasting cacao genotypes to witches' broom disease reveals differential accumulation of PR proteins.Frontiers in plant science · 2024Article
- Genomic insights into bamboo witches' broom disease: pathogenicity and phytohormone biosynthesis inFrontiers in microbiology · 2024Article
- The mMolecular plant pathology · 2023Article
- Article
- BASIDIN as a New Protein Effector of the Phytopathogen Causing Witche's Broom Disease in Cocoa.International journal of molecular sciences · 2023Article
- Comparative transcriptome analysis of juniper branches infected by Gymnosporangium spp. highlights their different infection strategies associated with cytokinins.BMC genomics · 2023Article
- TcTI, a Kunitz-type trypsin inhibitor from cocoa associated with defense against pathogens.Scientific reports · 2022Article
- Characterization of the microbiota dynamics associated withFrontiers in microbiology · 2022Article
- Mixed Transcriptome Analysis Revealed the Possible Interaction Mechanisms betweenInternational journal of molecular sciences · 2021Article
- Article
- Loss of function of a DMR6 ortholog in tomato confers broad-spectrum disease resistance.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Plant SWEETs: from sugar transport to plant-pathogen interaction and more unexpected physiological roles.Plant physiology · 2021Review
- Adaptive evolution of Moniliophthora PR-1 proteins towards its pathogenic lifestyle.BMC ecology and evolution · 2021Article
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12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Witches' broom disease (WBD), caused by the hemibiotrophic fungus Moniliophthora perniciosa, is one of the most devastating diseases of Theobroma cacao, the chocolate tree. In contrast to other hemibiotrophic interactions, the WBD biotrophic stage lasts for months and is responsible for the most distinctive symptoms of the disease, which comprise drastic morphological changes in the infected shoots. Here, we used the dual RNA-seq approach to simultaneously assess the transcriptomes of cacao and M. perniciosa during their peculiar biotrophic interaction. Infection with M. perniciosa triggers massive metabolic reprogramming in the diseased tissues. Although apparently vigorous, the infected shoots are energetically expensive structures characterized by the induction of ineffective defense responses and by a clear carbon deprivation signature. Remarkably, the infection culminates in the establishment of a senescence process in the host, which signals the end of the WBD biotrophic stage. We analyzed the pathogen's transcriptome in unprecedented detail and thereby characterized the fungal nutritional and infection strategies during WBD and identified putative virulence effectors. Interestingly, M. perniciosa biotrophic mycelia develop as long-term parasites that orchestrate changes in plant metabolism to increase the availability of soluble nutrients before plant death. Collectively, our results provide unique insight into an intriguing tropical disease and advance our understanding of the development of (hemi)biotrophic plant-pathogen interactions.
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