Evidence map›Paper›PMID 25371442›Full record

ArticleAnnals of the rheumatic diseases2016

Myeloid-derived suppressor cells have a proinflammatory role in the pathogenesis of autoimmune arthritis.

Chunqing Guo, Fanlei Hu, Huanfa Yi, Zhitao Feng, Changzheng Li, Lianjie Shi, Yingni Li, Hongjiang Liu, Xiaofei Yu, Hongxia Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the rheumatic diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 157 citations in OpenAlex.

  1. Article
  2. Review
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  4. Myeloid-Derived Suppressor Cells in Inflammatory Arthritis.International journal of molecular sciences · 2026
    Review
  5. Article
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  9. Characterizing the Emergence of Myeloid-Derived Suppressor Cell Subsets in a Murine Model of Pulmonary Fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Chunqing GuoDepartment of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA Virginia Commonwealth University Institute of Molecular Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA Virginia Commonwealth University Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Fanlei HuDepartment of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
Huanfa YiDepartment of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA Virginia Commonwealth University Institute of Molecular Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA Virginia Commonwealth University Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA Institute of Immunology, First Bethune Hospital of Jilin University, Changchun, Jilin, China.
Zhitao FengDepartment of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Changzheng LiDepartment of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Lianjie ShiDepartment of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
Yingni LiDepartment of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
Hongjiang LiuDepartment of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
Xiaofei YuDepartment of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA Virginia Commonwealth University Institute of Molecular Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA Virginia Commonwealth University Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Hongxia WangDepartment of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA Virginia Commonwealth University Institute of Molecular Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA Virginia Commonwealth University Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Juan LiDepartment of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Zhanguo LiDepartment of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
Xiang-Yang WangDepartment of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA Virginia Commonwealth University Institute of Molecular Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA Virginia Commonwealth University Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Virginia Commonwealth University · USPeking University People's Hospital · CNPeking University · CNSouthern Medical University · CNNanfang Hospital · CN

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Paula Daniela Bos · 1985 to 2026
$51.0M
Host-tumor interactions and cancer relapse after radiation therapyR01CA175033 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI WANG, XIANG-YANG SHAWN · 2014 to 2018
$1.6M
Large Stress Proteins in Biology and MedicineR01CA154708 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI WANG, XIANG-YANG SHAWN · 2011 to 2015
$1.5M
NCI NIH HHS CA154708NCI NIH HHS CA175033NCI NIH HHS P30 CA016059NCI NIH HHS R01 CA154708NCI NIH HHS R01 CA175033
6 · The paper itself

Abstract

objectivesAlthough myeloid-derived suppressor cells (MDSCs) have been linked to T cell tolerance, their role in autoimmune rheumatoid arthritis (RA) remains elusive. Here we investigate the potential association of MDSCs with the disease pathogenesis using a preclinical model of RA and specimen collected from patients with RA.

methodsThe frequency of MDSCs in blood, lymphoid tissues, inflamed paws or synovial fluid and their association with disease severity, tissue inflammation and the levels of pathogenic T helper (Th) 17 cells were examined in arthritic mice or in patients with RA (n=35) and osteoarthritis (n=15). The MDSCs in arthritic mice were also characterised for their phenotype, inflammation status, T cell suppressive activity and their capacity of pro-Th17 cell differentiation. The involvement of MDSCs in the disease pathology and a Th17 response was examined by adoptive transfer or antibody depletion of MDSCs in arthritic mice or by coculturing mouse or human MDSCs with naïve CD4+ T cells under Th17-polarising conditions.

resultsMDSCs significantly expanded in arthritic mice and in patients with RA, which correlated positively with disease severity and an inflammatory Th17 response. While displaying T cell suppressive activity, MDSCs from arthritic mice produced high levels of inflammatory cytokines (eg, interleukin (IL)-1β, TNF-α). Mouse and human MDSCs promoted Th17 cell polarisation ex vivo. Transfer of MDSCs facilitated disease progression, whereas their elimination in arthritic mice ameliorated disease symptoms concomitant with reduction of IL-17A/Th17 cells.

conclusionsOur studies suggest that proinflammatory MDSCs with their capacity to drive Th17 cell differentiation may be a critical pathogenic factor in autoimmune arthritis.

Indexed as

AnimalsArthritis, ExperimentalArthritis, RheumatoidAutoimmune DiseasesCD4-Positive T-LymphocytesCell DifferentiationCoculture TechniquesDisease ProgressionHumansImmune ToleranceMaleMice, Inbred C57BLMyeloid CellsOsteoarthritisSeverity of Illness IndexSynovial Fluid

Identifiers

PMID25371442
PMCPMC4418961
OpenAlexW2135713509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.