Evidence map›Paper›PMID 25371357›Full record

ReviewDevelopment (Cambridge, England)2014

Chemokine signaling in development and disease.

John Wang, Holger Knaut

Open access · bronzeAbstract readReview
In one paragraph

Review in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 1 synthesis or guideline pooled it, 157 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Chemokines in Pregnancy.Biomolecules · 2025
    Review
  6. Article
  7. Review
  8. CXCR4Nature communications · 2025
    Article
  9. Article
  10. Unveiling immune mechanisms and potential biomarkers in intervertebral disc degeneration through integrated analysis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

John WangDevelopmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University Langone Medical Center, New York, NY 10016, USA.
Holger KnautDevelopmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University Langone Medical Center, New York, NY 10016, USA Kimmel Center for Stem Cell Biology, New York University Langone Medical Center, New York, NY 10016, USA holger.knaut@med.nyu.edu.
NYU Langone Health · US

Funding

TRAINING PROGRAM IN DEVELOPMENTAL GENETICS.T32HD007520 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TREISMAN, JESSICA E · 1999 to 2023
$3.9M
Molecular Regulation of Trigeminal Sensory Ganglia DevelopmentR01NS069839 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KNAUT, HOLGER · 2011 to 2016
$2.2M
Shaping a chemotactic signal in a complex environmentF30HD079229 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WANG, JOHN · 2014 to 2016
$110k
NICHD NIH HHS F30 HD079229NICHD NIH HHS HD007520NICHD NIH HHS T32 HD007520NINDS NIH HHS NS069839NINDS NIH HHS R01 NS069839
6 · The paper itself

Abstract

Chemokines are a group of small, secreted molecules that signal through G protein-coupled receptors to promote cell survival and proliferation and to provide directional guidance to migrating cells. CXCL12 is one of the most evolutionary conserved chemokines and signals through the chemokine receptor CXCR4 to guide cell migration during embryogenesis, immune cell trafficking and cancer metastasis. Here and in the accompanying poster, we provide an overview of chemokine signaling, focusing on CXCL12, and we highlight some of the different chemokine-dependent strategies used to guide migrating cells.

Indexed as

AnimalsCell MovementChemokine CXCL12ChemokinesEmbryonic DevelopmentHumansImmunity, CellularNeoplasm MetastasisSignal TransductionChemokine CXCL12ChemokinesCell migrationChemokineCXCL12CXCR4GPCR

Identifiers

PMID25371357
PMCPMC4302920
OpenAlexW2072755258

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.