ArticleTransfusion2015
Transfusion-related adverse reactions reported to the National Healthcare Safety Network Hemovigilance Module, United States, 2010 to 2012.
Article in Transfusion, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Effect of post-storage filters vs. pre-storage filters for leukoreduction of blood components on clinical outcomes: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2023Pooled it
- Development and improvement of Chinese Haemovigilance Network from 2018 to 2023.Vox sanguinis · 2026Article
- Red blood cell transfusions in advanced cancer near the end-of-life: narrative review.BMJ supportive & palliative care · 2026Review
- The evolving landscape of platelet therapy: risks, innovations, and clinical judgment.Annals of hematology · 2026Review
- Reframing ATR: from the immunologic/nonimmunologic dichotomy to adaptive, innate, and physicochemical drivers within the allergy-inflammation-coagulation axis.Frontiers in immunology · 2026Review
- A single center experience of transfusion related adverse reaction in pediatric patients with malignant solid and hematological tumors.Frontiers in pediatrics · 2026Article
- The Effect of Autologous Blood Transfusion in Open Heart Procedures on the Requirement of Allogeneic Blood Products.Cureus · 2025Article
- Hospitalizations with blood transfusions and transfusion-related adverse events in US acute care hospitals, 2016-2020.Transfusion · 2025Article
- Time series forecasting of red blood cell demand in hematology patients using SARIMA and exponential smoothing models: a retrospective analysis in a Chinese tertiary hospital.Frontiers in medicine · 2025Article
- The effect of the leukoreduction filtration moment on the clinical outcome of transfused patients: A retrospective cohort study.Clinics (Sao Paulo, Brazil) · 2025Article
- Is Preoperative Type and Screen High-value Care? A Cost-effectiveness Analysis of Performing Preoperative Type and Screen Prior to Urogynecological Surgery.International urogynecology journal · 2024Article
- Incomplete tissue product tracing during an investigation of a tissue-derived tuberculosis outbreak.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Platelet versus fresh frozen plasma transfusion for coagulopathy in cardiac surgery patients.PloS one · 2024Article
- Review of haemovigilance at the Rabat Regional Blood Transfusion Centre in Morocco (2017-2021).The Pan African medical journal · 2024Article
- Transfusion practices in intensive care units: An Australian and New Zealand point prevalence study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2023Article
- Blood Transfusion Complications and Associated Factors Among Blood-Transfused Adult Patients at Debre Markos Comprehensive Specialized Hospital, Ethiopia: A Cross Sectional Study.Journal of blood medicine · 2023Article
- Research progress on febrile non-hemolytic transfusion reaction: a narrative review.Annals of translational medicine · 2022Review
- Severe Acute Hemolytic Transfusion Reaction Treated with Ruxolitinib and Plasma Exchange.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2021Article
- A Comparison of Transfusion-Related Adverse Reactions Among Apheresis Platelets, Whole Blood-Derived Platelets, and Platelets Subjected to Pathogen Reduction Technology as Reported to the National Healthcare Safety Network Hemovigilance Module.Transfusion medicine reviews · 2021Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn 2010, health care facilities in the United States began voluntary enrollment in the National Healthcare Safety Network (NHSN) Hemovigilance Module. Participants report transfusion practices; red blood cell, platelet (PLT), plasma, and cryoprecipitate units transfused; and transfusion-related adverse reactions and process errors to the Centers for Disease Control and Prevention through a secure, Internet-accessible surveillance application available to transfusing facilities. STUDY DESIGN AND
methodsFacilities submitting at least 1 month of transfused components data and adverse reactions from January 1, 2010, to December 31, 2012, were included in this analysis. Adverse reaction rates for transfused components, stratified by component type and collection and modification methods, were calculated.
resultsIn 2010 to 2012, a total of 77 facilities reported 5136 adverse reactions among 2,144,723 components transfused (239.5/100,000). Allergic (46.8%) and febrile nonhemolytic (36.1%) reactions were most frequent; 7.2% of all reactions were severe or life-threatening and 0.1% were fatal. PLT transfusions (421.7/100,000) had the highest adverse reaction rate.
conclusionAdverse transfusion reaction rates from the NHSN Hemovigilance Module in the United States are comparable to early hemovigilance reporting from other countries. Although severe reactions are infrequent, the numbers of transfusion reactions in US hospitals suggest that interventions to prevent these reactions are important for patient safety. Further investigation is needed to understand the apparent increased risk of reactions from apheresis-derived blood components. Comprehensive evaluation, including data validation, is important to continued refinement of the module.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.