ArticleThe Journal of biological chemistry2015
A juvenile hormone transcription factor Bmdimm-fibroin H chain pathway is involved in the synthesis of silk protein in silkworm, Bombyx mori.
Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Targeting the circadian negative regulatorMaterials today. Bio · 2026Article
- Revealing the Mechanisms of Alzheimer's, Parkinson's and Huntington's Diseases Through Invertebrate Models.Biology · 2026Review
- Single-Cell Deconvolution Reveals Phenotype-Associated Cellular States in the Silk Glands ofInsects · 2026Article
- Article
- Regionalization of gene expression and cell types in the silk gland of the pantry mothbioRxiv : the preprint server for biology · 2025Article
- Article
- BmHR3 Is Essential for Silk Gland Development and Silk Protein Synthesis in Silkworms (Insects · 2025Article
- Article
- Juvenile hormone regulates silk gene expression by mCellular and molecular life sciences : CMLS · 2023Article
- Overexpression ofInternational journal of molecular sciences · 2023Article
- Global Profiling of Genes Expressed in the Silk Glands of Philippine-Reared Mulberry SilkwormsInsects · 2022Article
- A single-cell transcriptomic atlas characterizes the silk-producing organ in the silkworm.Nature communications · 2022Article
- Dynamics of nuclear matrix attachment regions during 5BMC genomics · 2022Article
- New insights into the proteins interacting with the promoters of silkworm fibroin genes.Scientific reports · 2021Article
- Genome-wide survey and characterization of transcription factors in the silk gland of the silkworm, Bombyx mori.PloS one · 2021Article
- Transgenic Ectopic Overexpression of Broad Complex (Insects · 2020Article
- Insights into the regulatory characteristics of silkworm fibroin gene promoters using a modified Gal4/UAS system.Transgenic research · 2019Article
- Deep Insight into the Transcriptome of the Single Silk Gland ofInternational journal of molecular sciences · 2019Article
- Article
- Insect Transcription Factors: A Landscape of Their Structures and Biological Functions inInternational journal of molecular sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genes responsible for silk biosynthesis are switched on and off at particular times in the silk glands of Bombyx mori. This switch appears to be under the control of endogenous and exogenous hormones. However, the molecular mechanisms by which silk protein synthesis is regulated by the juvenile hormone (JH) are largely unknown. Here, we report a basic helix-loop-helix transcription factor, Bmdimm, its silk gland-specific expression, and its direct involvement in the regulation of fibroin H-chain (fib-H) by binding to an E-box (CAAATG) element of the fib-H gene promoter. Far-Western blots, enzyme-linked immunosorbent assays, and co-immunoprecipitation assays revealed that Bmdimm protein interacted with another basic helix-loop-helix transcription factor, Bmsage. Immunostaining revealed that Bmdimm and Bmsage proteins are co-localized in nuclei. Bmdimm expression was induced in larval silk glands in vivo, in silk glands cultured in vitro, and in B. mori cell lines after treatment with a JH analog. The JH effect on Bmdimm was mediated by the JH-Met-Kr-h1 signaling pathway, and Bmdimm expression did not respond to JH by RNA interference with double-stranded BmKr-h1 RNA. These data suggest that the JH regulatory pathway, the transcription factor Bmdimm, and the targeted fib-H gene contribute to the synthesis of fibroin H-chain protein in B. mori.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.