ArticleAmerican journal of epidemiology2014
Elevated lung cancer in younger adults and low concentrations of arsenic in water.
Article in American journal of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Glutathione Transferases Omega-1 and -2 Polymorphisms in Cancer: Drivers or Silent Bystanders?International journal of molecular sciences · 2025Pooled it
- Interaction between Occupational and Non-Occupational Arsenic Exposure and Tobacco Smoke on Lung Cancerogenesis: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Use of study-specific MOE-like estimates to prioritize health effects from chemical exposure for analysis in human health assessments.Environment international · 2020Pooled it
- Biomonitoring and Health Risk Assessment of Arsenic Contamination in Drinking Water among Rural Residents in Western Tehran.PloS one · 2025Article
- A Feasibility Study to Mitigate Arsenic Exposure in Well Water in Oregon.Journal of extension · 2025Article
- Long-Term Exposure to Arsenic in Community Water Supplies and Risk of Cardiovascular Disease among Women in the California Teachers Study.Environmental health perspectives · 2024Article
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- An appraisal of the principal concerns and controlling factors for Arsenic contamination in Chile.Scientific reports · 2023Article
- Synergy of arsenic with smoking in causing cardiovascular disease mortality: A cohort study with 27 follow-up years in China.Frontiers in public health · 2022Article
- Curcumin prevents AsChinese medicine · 2021Article
- Firing Increases Arsenic Leaching from Ceramic Water Filters via Arsenic and Iron Phase Transformations.Environmental science & technology · 2021Article
- Association of arsenic-induced cardiovascular disease susceptibility with genetic polymorphisms.Scientific reports · 2021Article
- Health effects of arsenic exposure in Latin America: An overview of the past eight years of research.The Science of the total environment · 2020Article
- Intra- and Interlaboratory Evaluation of an Assay of Soil Arsenic Relative Bioavailability in Mice.Journal of agricultural and food chemistry · 2020Article
- Urinary metals and metal mixtures in midlife women: The Study of Women's Health Across the Nation (SWAN).International journal of hygiene and environmental health · 2019Article
- Screening of key genes and prediction of therapeutic agents in Arsenic-induced lung carcinoma.Cancer biomarkers : section A of Disease markers · 2019Article
- Association between lung cancer risk and inorganic arsenic concentration in drinking water: a dose-response meta-analysis.Toxicology research · 2018Article
- Nutritional Influences on One-Carbon Metabolism: Effects on Arsenic Methylation and Toxicity.Annual review of nutrition · 2018Review
- Lung Cancer Risk and Low (≤50 μg/L) Drinking Water Arsenic Levels for US Counties (2009⁻2013)-A Negative Association.International journal of environmental research and public health · 2018Article
- Increased O-GlcNAcylation of SNAP29 Drives Arsenic-Induced Autophagic Dysfunction.Molecular and cellular biology · 2018Article
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10 authors at 1 institution in 1 country.
Funding
Abstract
Arsenic concentrations greater than 100 µg/L in drinking water are a known cause of cancer, but the risks associated with lower concentrations are less well understood. The unusual geology and good information on past exposure found in northern Chile are key advantages for investigating the potential long-term effects of arsenic. We performed a case-control study of lung cancer from 2007 to 2010 in areas of northern Chile that had a wide range of arsenic concentrations in drinking water. Previously, we reported evidence of elevated cancer risks at arsenic concentrations greater than 100 µg/L. In the present study, we restricted analyses to the 92 cases and 288 population-based controls who were exposed to concentrations less than 100 µg/L. After adjustment for age, sex, and smoking behavior, these exposures from 40 or more years ago resulted in odds ratios for lung cancer of 1.00, 1.43 (90% confidence interval: 0.82, 2.52), and 2.01 (90% confidence interval: 1.14, 3.52) for increasing tertiles of arsenic exposure, respectively (P for trend = 0.02). Mean arsenic water concentrations in these tertiles were 6.5, 23.0, and 58.6 µg/L. For subjects younger than 65 years of age, the corresponding odds ratios were 1.00, 1.62 (90% confidence interval: 0.67, 3.90), and 3.41 (90% confidence interval: 1.51, 7.70). Adjustments for occupation, fruit and vegetable intake, and socioeconomic status had little impact on the results. These findings provide new evidence that arsenic water concentrations less than 100 µg/L are associated with higher risks of lung cancer.
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