ArticleMolecular neurobiology2015
Identifying the Association Between Alzheimer's Disease and Parkinson's Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network.
Article in Molecular neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- PICALM rs3851179 Variant Confers Susceptibility to Alzheimer's Disease in Chinese Population.Molecular neurobiology · 2017Pooled it
- A Multi-Locus and Machine Learning-Based Assessment of SNCA Variants in Alzheimer's Disease.International journal of molecular sciences · 2026Article
- Shared Pathogenic Pathways Between REM Sleep Behavior Disorder and Neurodegenerative and Psychiatric Disorders.medRxiv : the preprint server for health sciences · 2026Article
- Stingless bee propolis: a comprehensive review of chemical constituents and health efficacy.Natural products and bioprospecting · 2025Review
- PLEKHM1 Overexpression Impairs Autophagy and Exacerbates Neurodegeneration in rAAV-α-Synuclein Mice.Cells · 2025Article
- Exploring patterns of multimorbidity in South Korea using exploratory factor analysis and non negative matrix factorization.Scientific reports · 2025Article
- Unveiling biomarker detection in Alzheimer's disease: a computational approach to microarray analysis.3 Biotech · 2024Article
- hipFG: high-throughput harmonization and integration pipeline for functional genomics data.Bioinformatics (Oxford, England) · 2023Article
- Neurodegeneration and Neuroinflammation in Parkinson's Disease: a Self-Sustained Loop.Current neurology and neuroscience reports · 2022Review
- Association and Gene-Gene Interactions Study of Late-Onset Alzheimer's Disease in the Russian Population.Genes · 2021Article
- Effect of plasma vitamin C levels on Parkinson's disease and age at onset: a Mendelian randomization study.Journal of translational medicine · 2021Article
- rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues.BMC medicine · 2021Article
- T1-weighted MRI-driven Brain Age Estimation in Alzheimer's Disease and Parkinson's Disease.Aging and disease · 2020Article
- Serum Calcium Levels and Parkinson's Disease: A Mendelian Randomization Study.Frontiers in genetics · 2020Article
- Parkinson's Disease Risk Variant rs1109303 Regulates the Expression of INPP5K and CRK in Human Brain.Neuroscience bulletin · 2019Article
- Parkinson's disease and Alzheimer's disease: a Mendelian randomization study.BMC medical genetics · 2018Article
- Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunction.Neurology. Genetics · 2018Article
- Alzheimer's Disease and Rheumatoid Arthritis: A Mendelian Randomization Study.Frontiers in neuroscience · 2018Article
- Rs4878104 contributes to Alzheimer's disease risk and regulates DAPK1 gene expression.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology.Frontiers in aging neuroscience · 2017Article
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) and Parkinson's disease (PD) are the first and second most common neurodegenerative diseases in the elderly. Shared clinical and pathological features have been reported. Recent large-scale genome-wide association studies (GWAS) have been conducted and reported a number of AD and PD variants. Until now, the underlying genetic mechanisms for all these newly identified PD variants as well as the association between AD and PD are still unclear exactly. We think that PD variants may contribute to AD and PD by influence on brain gene expression. Here, we conducted a systems analysis using (1) AD and PD variants (P < 5.00E-08) identified by the published GWAS; (2) four brain expression GWAS datasets using expression quantitative trait loci from the cerebellum and temporal cortex; (3) large-scale AD GWAS from the Alzheimer Disease Genetics Consortium (ADGC); (4) a protein-protein interaction network. Our results indicated that PD variants around the 17q21 were associated with gene expression and suggestive AD risk. We also identified significant interaction among AD and PD susceptibility genes. We believe that our findings may explain the underlying genetic mechanisms for newly identified PD variants in PD and AD, as well as the association between AD and PD, which may be very useful for future genetic studies for both diseases.
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