Evidence map›Paper›PMID 25370597›Full record

ArticleClinical journal of the American Society of Nephrology : CJASN2015

Association of urine α1-microglobulin with kidney function decline and mortality in HIV-infected women.

Vasantha Jotwani, Rebecca Scherzer, Alison Abraham, Michelle M Estrella, Michael Bennett, Mardge H Cohen, Marek Nowicki, Anjali Sharma, Mary Young, Phyllis C Tien and 4 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical journal of the American Society of Nephrology : CJASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 62 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Effects of Intensive Blood Pressure Lowering on Kidney Tubule Injury in CKD: A Longitudinal Subgroup Analysis in SPRINT.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019
    Trial
  6. Trial
  7. Urine Fibrosis Markers and Risk of Allograft Failure in Kidney Transplant Recipients: A Case-Cohort Ancillary Study of the FAVORIT Trial.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017
    Trial
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Vasantha JotwaniDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Rebecca ScherzerDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Alison AbrahamDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Michelle M EstrellaDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Michael BennettDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Mardge H CohenDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Marek NowickiDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Anjali SharmaDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Mary YoungDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Phyllis C TienDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Joachim H IxDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Mark J SarnakDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Chirag R ParikhDue to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Michael G ShlipakDue to the number of contributing authors, the affiliations are provided in the Supplemental Material. Michael.Shlipak@ucsf.edu.
San Francisco VA Medical Center · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Emory WIHS CRS - Longitudinal CohortU01AI103408 · NIAID · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WINGOOD, GINA MARIA · 2013 to 2018
$14.1M
UAB-MISS WIHS CohortU01AI103401 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEMPF, MIRJAM-COLETTE, KONKLE-PARKER, DEBORAH J · 2013 to 2018
$11.2M
University of North Carolina Womens Interagency HIV Study UNC WIHSU01AI103390 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADIMORA, ADAORA A · 2013 to 2018
$11.0M
FIC NIH HHS D43 TW001035NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1-TR000004NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1-TR000454NIAID NIH HHS U01 AI031834NIAID NIH HHS U01-AI-031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01-AI-034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01-AI-034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01-AI-034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01-AI-035004NIAID NIH HHS U01 AI042590NIAID NIH HHS U01-AI-042590NIAID NIH HHS U01 AI103390NIAID NIH HHS U01-AI-103390NIAID NIH HHS U01 AI103397NIAID NIH HHS U01-AI-103397NIAID NIH HHS U01 AI103401NIAID NIH HHS U01-AI-103401NIAID NIH HHS U01 AI103408NIAID NIH HHS U01-AI-103408NIAMS NIH HHS K23 AR061993NIA NIH HHS 1 R01AG034853-01A2NIA NIH HHS R01 AG034853NICHD NIH HHS U01 HD032632NICHD NIH HHS U01-HD-032632NIDDK NIH HHS 1K23-DK-081317NIDDK NIH HHS K23 DK081317
6 · The paper itself

Abstract

BACKGROUND AND

objectivesDespite advances in therapy, HIV-infected individuals remain at higher risk for kidney dysfunction than uninfected individuals. It was hypothesized that urine levels of α1-microglobulin, a biomarker of proximal tubular dysfunction, would predict kidney function decline and mortality risk in HIV-infected and uninfected women. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In the Women's Interagency HIV Study, urine α1-microglobulin and creatinine concentrations were measured in 903 HIV-infected and 287 uninfected women using stored urine from 1999 to 2000, when prevalence of tenofovir use was <1%. Participants were categorized into three categories by level of α1-microglobulin-to-creatinine ratio, and associations with kidney decline and all-cause mortality over 8 years were evaluated.

resultsUrine α1-microglobulin was detectable in 60% of HIV-infected and 40% of uninfected women (P<0.001). Among HIV-infected women, there were 177 (22%), 61 (7%), and 128 (14%) patients with incident CKD, with 10% annual eGFR decline, and who died, respectively. Compared with HIV-infected women in the lowest α1-microglobulin category, HIV-infected women in the highest α1-microglobulin category had a 2.1-fold risk of incident CKD (95% confidence interval, 1.3 to 3.4), 2.7-fold risk of 10% annual eGFR decline (95% confidence interval, 1.2 to 5.9), and 1.6-fold mortality risk (95% confidence interval, 1.0 to 2.6) in models adjusting for kidney risk factors, baseline eGFR, and albuminuria. Among uninfected women, the highest α1-microglobulin category was associated with 3% (relative risk, 2.2; 95% confidence interval, 1.4 to 3.5) and 5% (relative risk, 2.2; 95% confidence interval, 1.1 to 4.3) annual eGFR decline relative to the lowest α1-microglobulin category.

conclusionsProximal tubular dysfunction, indicated by urine α1-microglobulin, was independently associated with kidney function decline in HIV-infected and uninfected women and mortality risk among HIV-infected women.

Indexed as

AdultAIDS-Associated NephropathyAlpha-GlobulinsBiomarkersCase-Control StudiesChi-Square DistributionCreatinineDisease ProgressionFemaleGlomerular Filtration RateHumansKidney Function TestsKidney Tubules, ProximalLinear ModelsMiddle AgedMultivariate Analysisalpha-1-microglobulinAlpha-GlobulinsBiomarkersCreatinineCKDHIV nephropathyproximal tubule

Identifiers

PMID25370597
PMCPMC4284407
OpenAlexW2156075424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.