Trial reportBrain imaging and behavior2015
Heterogeneity of neural mechanisms of response to pivotal response treatment.
Trial report in Brain imaging and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- A systematic review of observational, naturalistic, and neurophysiological outcome measures of nonpharmacological interventions for autism.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2022Pooled it
- The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder.Journal of autism and developmental disorders · 2022Trial
- Neural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward.Journal of child and adolescent psychopharmacology · 2016Trial
- Acute, chronic and conditioned effects of intranasal oxytocin in the mu-opioid receptor knockout mouse model of autism: Social context matters.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- A neuro-computational social learning framework to facilitate transdiagnostic classification and treatment across psychiatric disorders.Neuroscience and biobehavioral reviews · 2023Review
- The Early Start Denver Model Intervention and Mu Rhythm Attenuation in Autism Spectrum Disorders.Journal of autism and developmental disorders · 2022Article
- Can EEG Correlates Predict Treatment Efficacy in Children with Overlapping ASD and SLI Symptoms: A Case Report.Diagnostics (Basel, Switzerland) · 2022Article
- Social Deficits or Interactional Differences? Interrogating Perspectives on Social Functioning in Autism.Frontiers in psychiatry · 2022Article
- Brain Functional Alterations in Prepubertal Boys With Autism Spectrum Disorders.Frontiers in human neuroscience · 2022Article
- Investigating Changes in Reward-Related Neural Correlates After PEERS Intervention in Adolescents With ASD: Preliminary Evidence of a "Precision Medicine" Approach.Frontiers in psychiatry · 2021Article
- Ayres Theories of Autism and Sensory Integration Revisited: What Contemporary Neuroscience Has to Say.Brain sciences · 2019Review
- Task Interspersal Implementation Practices with Individuals with Autism Spectrum Disorder.Behavior analysis in practice · 2019Article
- Neurodevelopmental Disorders Affecting Sociability: Recent Research Advances and Future Directions in Autism Spectrum Disorder and Williams Syndrome.Current neurology and neuroscience reports · 2018Review
- Back-translating behavioral intervention for autism spectrum disorders to mice with blunted reward restores social abilities.Translational psychiatry · 2018Article
- Neural mechanisms of behavioral change in young adults with high-functioning autism receiving virtual reality social cognition training: A pilot study.Autism research : official journal of the International Society for Autism Research · 2018Article
- Brief report: Reduced anxiety following Pivotal Response Treatment in young children with Autism Spectrum Disorder.Research in autism spectrum disorders · 2017Article
- Pivotal response treatment for autism spectrum disorder: current perspectives.Neuropsychiatric disease and treatment · 2017Review
- Brain responses to biological motion predict treatment outcome in young children with autism.Translational psychiatry · 2016Article
- To Screen or Not to Screen Universally for Autism is not the Question: Why the Task Force Got It Wrong.The Journal of pediatrics · 2016Article
- Brief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment.Journal of autism and developmental disorders · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We investigated the mechanisms by which Pivotal Response Treatment (PRT) improves social communication in a case series of 10 preschool-aged children with Autism Spectrum Disorder (ASD). Functional magnetic resonance imaging (fMRI) identified brain responses during a biological motion perception task conducted prior to and following 16 weeks of PRT treatment. Overall, the neural systems supporting social perception in these 10 children were malleable through implementation of PRT; following treatment, neural responses were more similar to those of typically developing children (TD). However, at baseline, half of the children exhibited hypoactivation, relative to a group of TD children, in the right posterior superior temporal sulcus (pSTS), and half exhibited hyperactivation in this region. Strikingly, the groups exhibited differential neural responses to treatment: The five children who exhibited hypoactivation at baseline evidenced increased activation in components of the reward system including the ventral striatum and putamen. The five children who exhibited hyperactivation at baseline evidenced decreased activation in subcortical regions critical for regulating the flow of stimulation and conveying signals of salience to the cortex-the thalamus, amygdala, and hippocampus. Our results support further investigation into the differential effects of particular treatment strategies relative to specific neural targets. Identification of treatment strategies that address the patterns of neural vulnerability unique to each patient is consistent with the priority of creating individually tailored interventions customized to the behavioral and neural characteristics of a given person.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.