ArticleExperimental brain research2015
Prehension synergies and hand function in early-stage Parkinson's disease.
Article in Experimental brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Age-related changes to motor synergies in multi-joint and multi-finger manipulative skills: a meta-analysis.European journal of applied physiology · 2019Pooled it
- Dopaminergic modulation of multi-muscle synergies in postural tasks performed by patients with Parkinson's disease.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2017Trial
- Finger force changes in the absence of visual feedback in patients with Parkinson's disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Trial
- Changes in synergy formation and modulation during cyclic finger force production tasks in female adults with dystonic cerebral palsy.Experimental brain research · 2026Article
- Error compensation in a redundant system during 'failure' of individual motor elements.Experimental brain research · 2025Article
- Force drifts and matching errors in the lower extremities: implications for the control and perception of foot force.Experimental brain research · 2024Article
- Two aspects of feed-forward control of action stability: effects of action speed and unexpected events.Experimental brain research · 2024Article
- Quantifying Changes in Dexterity as a Result of Piano Training in People with Parkinson's Disease.Sensors (Basel, Switzerland) · 2024Article
- Motor unit-based synergies in a non-compartmentalized muscle.Experimental brain research · 2023Article
- Synergic control in asymptomatic welders during multi-finger force exertion and load releasing while standing.Neurotoxicology · 2022Article
- Expectation of volitional arm movement has prolonged effects on the grip force exerted on a pinched object.Experimental brain research · 2022Article
- Unintentional force drifts across the human fingers: implications for the neural control of finger tasks.Experimental brain research · 2022Article
- One more time about motor (and non-motor) synergies.Experimental brain research · 2021Review
- Number of Trials Necessary to Apply Analysis Within the Framework of the Uncontrolled Manifold Hypothesis at Different Levels of Hierarchical Synergy Control.Journal of human kinetics · 2021Article
- Synergic control of action in levodopa-naïve Parkinson's disease patients: I. Multi-finger interaction and coordination.Experimental brain research · 2020Article
- Quantitative analysis of multi-element synergy stabilizing performance: comparison of three methods with respect to their use in clinical studies.Experimental brain research · 2019Article
- Individual preferences in motor coordination seen across the two hands: relations to movement stability and optimality.Experimental brain research · 2019Article
- Muscle coactivation: definitions, mechanisms, and functions.Journal of neurophysiology · 2018Review
- Systemic effects of deep brain stimulation on synergic control in Parkinson's disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Article
- Welding-related brain and functional changes in welders with chronic and low-level exposure.Neurotoxicology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
We explored the multi-digit synergies and hand performance in object manipulations and pressing tasks in patients with early-stage Parkinson's disease (PD) and healthy controls. Synergies were defined as inter-trials co-variation patterns among forces/moments produced by individual digits that stabilized a resultant mechanical variable. The subjects performed three main tasks: pressing (steady-state force production followed by a force pulse into the target), prehension (manipulation of a handheld instrumented handle imitating the action of taking a sip from a glass), and functional object manipulation (moving a glass with water as quickly and accurately as possible along a chain of targets). The PD patients were slower compared to controls in all three tasks. Patients showed smaller synergy indices in the pressing and prehension tasks. In the prehension tasks, patients showed elevated grip force at steady states with smaller grip force modulation during the handle motion. PD patients showed smaller feed-forward synergy adjustments in preparation to the quick action in the pressing and (to a smaller degree) prehension tasks. Synergy indices correlated with the time index of performance in the functional glass-with-water task, whereas none of the indices correlated with the Unified PD Rating Scale part III-motor scores. We interpret the results as pointing at an important role of subcortical structures in motor synergies and their feed-forward adjustments to action.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.