ArticleProceedings of the National Academy of Sciences of the United States of America2014
Signaling pathways activated by a protease allergen in basophils.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Microbial sensing through the non-canonical inflammasome modulates airway type 2 immunity.Frontiers in immunology · 2026Article
- Carbonic anhydrase 8 regulates basophil activation and interleukin 4 production.Frontiers in immunology · 2025Article
- The origins and longevity of IgE responses as indicated by serological and cellular studies in mice and humans.Allergy · 2023Review
- Review
- IL-1α and IL-36 Family Cytokines Can Undergo Processing and Activation by Diverse Allergen-Associated Proteases.Frontiers in immunology · 2022Article
- The Transcription Factor PLZF Is Necessary for the Development and Function of Mouse Basophils.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Effects of the Th2-dominant milieu on allergic responses in Der f 1-activated mouse basophils and mast cells.Scientific reports · 2018Article
- Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33.Nature immunology · 2018Article
- The Hunt for the Source of Primary Interleukin-4: How We Discovered That Natural Killer T Cells and Basophils Determine T Helper Type 2 Cell DifferentiationFrontiers in immunology · 2018Review
- Ouabain attenuates ovalbumin-induced airway inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Basophil-derived IL-4 plays versatile roles in immunity.Seminars in immunopathology · 2016Review
- Promising candidates for allergy prevention.The Journal of allergy and clinical immunology · 2015Review
- Integrated innate mechanisms involved in airway allergic inflammation to the serine protease subtilisin.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Induction of Protective Immune Responses Against Schistosomiasis haematobium in Hamsters and Mice Using Cysteine Peptidase-Based Vaccine.Frontiers in immunology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Allergic diseases represent a significant burden in industrialized countries, but why and how the immune system responds to allergens remain largely unknown. Because many clinically significant allergens have proteolytic activity, and many helminths express proteases that are necessary for their life cycles, host mechanisms likely have evolved to detect the proteolytic activity of helminth proteases, which may be incidentally activated by protease allergens. A cysteine protease, papain, is a prototypic protease allergen that can directly activate basophils and mast cells, leading to the production of cytokines, including IL-4, characteristic of the type 2 immune response. The mechanism of papain's immunogenic activity remains unknown. Here we have characterized the cellular response activated by papain in basophils. We find that papain-induced IL-4 production requires calcium flux and activation of PI3K and nuclear factor of activated T cells. Interestingly, papain-induced IL-4 production was dependent on the immunoreceptor tyrosine-based activation motif (ITAM) adaptor protein Fc receptor γ-chain, even though the canonical ITAM signaling was not activated by papain. Collectively, these data characterize the downstream signaling pathway activated by a protease allergen in basophils.
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