ArticleNature communications2014
ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Temporal refinement of Dach1 expression contributes to the development of somatosensory neurons.The EMBO journal · 2025Article
- Palmitoylation by ZDHHC4 inhibits TRPV1-mediated nociception.EMBO reports · 2025Article
- Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia.iScience · 2023Article
- Glial Populations in the Human Brain Following Ischemic Injury.Biomedicines · 2023Review
- Transcriptional Alterations of Mouse Trigeminal Ganglion Neurons Following Orofacial Inflammation Revealed by Single-Cell Analysis.Frontiers in cellular neuroscience · 2022Article
- Nutritional Supplements for the Treatment of Neuropathic Pain.Biomedicines · 2021Review
- ZBTB20 Positively Regulates Oxidative Stress, Mitochondrial Fission, and Inflammatory Responses of ox-LDL-Induced Macrophages in Atherosclerosis.Oxidative medicine and cellular longevity · 2021Article
- Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3.Journal of inflammation research · 2021Article
- ZBTB20 in Nociceptive Neurons of the Trigeminal Ganglia Regulates Pruritus.Frontiers in medicine · 2021Article
- Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis.Osteoarthritis and cartilage · 2020Article
- MZF1 in the Dorsal Root Ganglia Contributes to the Development and Maintenance of Neuropathic Pain via Regulation of TRPV1.Neural plasticity · 2019Article
- ZBTB20 regulates EGFR expression and hepatocyte proliferation in mouse liver regeneration.Cell death & disease · 2018Article
- Quantitative meta-analytic approaches for the systematic synthesis of data and hazard identification: A case study of decreased pain sensitivity due to trimethylbenzene exposure.Environmental research · 2017Article
- Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons.Scientific reports · 2017Article
- Article
- ZBTB20 is required for anterior pituitary development and lactotrope specification.Nature communications · 2016Article
- Neuron-Specific Deletion of the Nf2 Tumor Suppressor Impairs Functional Nerve Regeneration.PloS one · 2016Article
- ZBTB20 is a sequence-specific transcriptional repressor of alpha-fetoprotein gene.Scientific reports · 2015Article
- Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
In mammals, pain sensation is initiated by the detection of noxious stimuli through specialized transduction ion channels and receptors in nociceptive sensory neurons. Transient receptor potential (TRP) channels are the key sensory transducers that confer nociceptors distinct sensory modalities. However, the regulatory mechanisms about their expression are poorly defined. Here we show that the zinc-finger protein ZBTB20 regulates TRP channels expression in nociceptors. ZBTB20 is highly expressed in nociceptive sensory neurons of dorsal root ganglia. Disruption of ZBTB20 in nociceptors led to a marked decrease in the expression levels of TRPV1, TRPA1 and TRPM8 and the response of calcium flux and whole-cell currents evoked by their respective specific agonists. Phenotypically, the mice lacking ZBTB20 specifically in nociceptors showed a defect in nociception and pain sensation in response to thermal, mechanical and inflammatory stimulation. Our findings point to ZBTB20 as a critical regulator of nociception and pain sensation by modulating TRP channels expression in nociceptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.