ArticleBlood transfusion = Trasfusione del sangue2015
In vitro evaluation of platelet concentrates suspended in additive solution and treated for pathogen reduction: effects of clumping formation.
Article in Blood transfusion = Trasfusione del sangue, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatelet concentrates may demonstrate visual, macroscopic clumps immediately after collection following aphaeresis or production from whole blood, independently of the preparation method or equipment used. The relationship between the occurrence of clumping and their effect on in vitro quality of platelets was investigated. MATERIAL AND
methodsPlatelet concentrates, suspended in SSP+ additive solution (Macopharma), were obtained by automated processing and also from routine processing. A total of twelve units were allocated to the test group (n=12) due to the presence of clumps. Platelet concentrates without clumps were used as controls (n=10). All platelet units were treated for pathogen reduction following storage under continuous agitation for in vitro testing over a 9-day storage period.
resultsNo significant differences were found throughout storage between the groups. The lactate dehydrogenase levels increased in both groups; this increase was higher in the test group on the last day of testing, without there being a significant difference on day 2. In contrast, pH values on day 2 were significantly different between the test and control groups. Platelet-derived cytokines increased comparably during storage. DISCUSSION: The results confirm good in vitro quality and storage stability of platelets suspended in SSP+ and treated with the Intercept pathogen reduction system. The presence of "non-compacted" clumps in platelet concentrates does not appear to affect the in vitro quality of the platelets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.