Trial reportAmerican journal of respiratory and critical care medicine2015
The preventability of ventilator-associated events. The CDC Prevention Epicenters Wake Up and Breathe Collaborative.
Trial report in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Does ventilator-associated event surveillance detect ventilator-associated pneumonia in intensive care units? A systematic review and meta-analysis.Critical care (London, England) · 2016Pooled it
- The impact of an intensive care telemedicine program on weaning from invasive ventilation: a secondary analysis of the ERIC trial.Critical care (London, England) · 2026Trial
- Comparison of SAT and SBT Conduct During the ABC Trial and PILOT Trial.Journal of intensive care medicine · 2025Trial
- Implementation of coordinated spontaneous awakening and breathing trials using telehealth-enabled, real-time audit and feedback for clinician adherence (TEACH): a type II hybrid effectiveness-implementation cluster-randomized trial.Implementation science : IS · 2023Trial
- Impact of a national collaborative project to improve the care of mechanically ventilated patients.PloS one · 2023Trial
- Impact of deep oropharyngeal suctioning on microaspiration, ventilator events, and clinical outcomes: A randomized clinical trial.Journal of advanced nursing · 2019Trial
- Preventing ICU Subsyndromal Delirium Conversion to Delirium With Low-Dose IV Haloperidol: A Double-Blind, Placebo-Controlled Pilot Study.Critical care medicine · 2016Trial
- A randomized controlled proof-of-concept trial of early sedation management using Responsiveness Index monitoring in mechanically ventilated critically ill patients.Critical care (London, England) · 2015Trial
- The preventability of ventilator-associated events. The CDC Prevention Epicenters Wake Up and Breathe Collaborative.American journal of respiratory and critical care medicine · 2015Trial
- Bayesian network model for identification of factors associated with ventilator-associated pneumonia in mechanically ventilated patients in the ICU: retrospective cohort study.BMC pulmonary medicine · 2026Article
- An Electronic Phenotype Series for Measuring Adherence to the Wake Up and Breathe Protocol in Mechanically Ventilated ICU Patients.Research square · 2026Article
- Incidence and risk factors of post-intensive care syndrome (PICS) in sepsis survivors: a prospective, observational study.BMC anesthesiology · 2025Observational
- Re-evaluating the impact of ventilator-associated events on mortality in critically ill patients: insights from advanced causal modeling.Intensive care medicine · 2025Article
- Normalizing daily awakening and breathing coordination at 15 heterogenous ICUs: a multicenter post-implementation survey.Implementation science communications · 2025Article
- Ventilator-Associated Pneumonia, Ventilator-Associated Events, and Nosocomial Respiratory Viral Infections on the Leeside of the Pandemic.Respiratory care · 2024Review
- Beyond Random Splitting: Evaluating the Impact of Data Partitioning Strategies on Ventilator-Associated Pneumonia Prediction Using EHRs.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Article
- Awakening and Breathing Coordination: A Mixed-Methods Analysis of Determinants of Implementation.Annals of the American Thoracic Society · 2023Article
- Implementing strategies to prevent infections in acute-care settings.Infection control and hospital epidemiology · 2023Article
- Enhancing the awakening to family engagement bundle with music therapy.World journal of critical care medicine · 2023Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
26 authors.
Funding
Abstract
rationaleThe CDC introduced ventilator-associated event (VAE) definitions in January 2013. Little is known about VAE prevention. We hypothesized that daily, coordinated spontaneous awakening trials (SATs) and spontaneous breathing trials (SBTs) might prevent VAEs.
objectivesTo assess the preventability of VAEs.
methodsWe nested a multicenter quality improvement collaborative within a prospective study of VAE surveillance among 20 intensive care units between November 2011 and May 2013. Twelve units joined the collaborative and implemented an opt-out protocol for nurses and respiratory therapists to perform paired daily SATs and SBTs. The remaining eight units conducted surveillance alone. We measured temporal trends in VAEs using generalized mixed effects regression models adjusted for patient-level unit, age, sex, reason for intubation, Sequential Organ Failure Assessment score, and comorbidity index. MEASUREMENTS AND MAIN
resultsWe tracked 5,164 consecutive episodes of mechanical ventilation: 3,425 in collaborative units and 1,739 in surveillance-only units. Within collaborative units, significant increases in SATs, SBTs, and percentage of SBTs performed without sedation were mirrored by significant decreases in duration of mechanical ventilation and hospital length-of-stay. There was no change in VAE risk per ventilator day but significant decreases in VAE risk per episode of mechanical ventilation (odds ratio [OR], 0.63; 95% confidence interval [CI], 0.42-0.97) and infection-related ventilator-associated complications (OR, 0.35; 95% CI, 0.17-0.71) but not pneumonias (OR, 0.51; 95% CI, 0.19-1.3). Within surveillance-only units, there were no significant changes in SAT, SBT, or VAE rates.
conclusionsEnhanced performance of paired, daily SATs and SBTs is associated with lower VAE rates. Clinical trial registered with www.clinicaltrials.gov (NCT 01583413).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.